Department of Ilmul Advia, Regional Research Institute of Unani Medicine, Srinagar, Jammu & Kashmir, India.
Biochemistry and Molecular Biology Lab., Division of Veterinary Biochemistry, Faculty of Veterinary Sciences & Animal Husbandry, Sher e Kashmir University of Agriculture Science and Technology-Kashmir (SKUAST-K), Srinagar, Jammu & Kashmir, India.
Redox Rep. 2021 Dec;26(1):94-104. doi: 10.1080/13510002.2021.1927396.
The current study was designed to examine the therapeutic role of hydroalcoholic extract of Roxb (CRE) and C.B. Clarke (PGE) on letrozole (1 mg/kg) induced polycystic ovary syndrome (PCOS) in female Wistar albino rats.
PCOS rats were treated with CRE (280 mg/kg), PGE (140 mg/kg) or CRE + PGE p.o. for 3 weeks. Vaginal smears for phase of estrous cycle determination, serum levels of sex androgens, lipid profile, oxidative stress parameters and histopathology of ovarian tissues were investigated.
Diestrous cycle days treated with CRE (group III) or PGE (group IV) decreased significantly ( < 0.05) compared to PCOS control animals (group II). Moreover, weight of uteri in PCOS animals treated with the plant extracts also increased significantly ( < 0.05) compared to that of group II animals. Histopathological examination showed the protective effect of the CRE and PGE indicated by the disappearance of ovarian cyst.
The study demonstrated that the CRE and PGE either alone or in combination hold a significant effect in letrozole induced PCOS rat models and could be useful in the management of reproductive and metabolic disorders related to PCOS.
本研究旨在探讨罗比（CRE）和 C.B.克拉克（PGE）的水醇提取物对来曲唑（1mg/kg）诱导的雌性 Wistar 白化大鼠多囊卵巢综合征（PCOS）的治疗作用。
用 CRE（280mg/kg）、PGE（140mg/kg）或 CRE+PGE 灌胃治疗 PCOS 大鼠 3 周。通过阴道涂片确定动情周期阶段，检测血清性激素、血脂谱、氧化应激参数和卵巢组织的组织病理学。
与 PCOS 对照组动物（第 II 组）相比，用 CRE（第 III 组）或 PGE（第 IV 组）处理的动情周期天数明显减少（<0.05）。此外，用植物提取物治疗的 PCOS 动物的子宫重量也明显增加（<0.05）与第 II 组动物相比。组织病理学检查显示 CRE 和 PGE 具有保护作用，表明卵巢囊肿消失。
该研究表明，CRE 和 PGE 单独或联合使用对来曲唑诱导的 PCOS 大鼠模型具有显著疗效，可用于治疗与 PCOS 相关的生殖和代谢紊乱。
