Immuno-Allergology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
Clin Exp Rheumatol. 2021 May-Jun;39(3):445-452. doi: 10.55563/clinexprheumatol/j1l5l3. Epub 2021 May 21.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterised by local and systemic inflammation where the close interaction between immune cells and soluble mediators leads to amplification and perpetuation of inflammatory and remodelling processes. The research carried out in the last year in the field of RA has made it possible to identify new mechanisms involved in the pathogenesis of the disease, enabling the discovery of new potential therapeutic targets. Thus, in this review we summarise new insights in RA pathogenesis, resulting from a literature research date published in the last year.
类风湿关节炎（RA）是一种慢性自身免疫性疾病，其特征为局部和全身炎症，免疫细胞和可溶性介质之间的密切相互作用导致炎症和重塑过程的放大和持续。过去一年在 RA 领域开展的研究使得有可能确定参与疾病发病机制的新机制，从而发现新的潜在治疗靶点。因此，在这篇综述中，我们总结了过去一年发表的文献中关于 RA 发病机制的新见解。
