Petrelli Fiorella, Mariani Francesco Maria, Alunno Alessia, Puxeddu Ilaria
Immuno-Allergology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
Internal Medicine and Nephrology Unit, Department of Life, Health and Environmental Sciences, University of L'Aquila, Italy.
Clin Exp Rheumatol. 2022 Mar;40(3):475-482. doi: 10.55563/clinexprheumatol/l9lyen. Epub 2022 Mar 10.
The mechanisms underlying the pathogenesis of rheumatoid arthritis (RA) involve different components of the immune system. In subjects with genetic predisposition to develop RA, a tight interaction between cells and mediators of the innate and adaptive immune system leads to the amplification and perpetuation of inflammation and tissue remodelling. The research carried out in the last year in the field of RA has improved the current knowledge on the pathogenesis of the disease, and is potentially useful to develop new therapeutic approaches. Thus, in this review we provide an overview on the new insights into RA pathogenesis, resulting from a literature search of the data published in the last year.
类风湿关节炎（RA）发病机制的潜在机制涉及免疫系统的不同组成部分。在具有RA遗传易感性的个体中，先天免疫系统和适应性免疫系统的细胞与介质之间的紧密相互作用会导致炎症的放大和持续以及组织重塑。去年在RA领域开展的研究增进了我们对该疾病发病机制的现有认识，并可能有助于开发新的治疗方法。因此，在本综述中，我们通过对去年发表的数据进行文献检索，概述了RA发病机制的新见解。
