Division of Physiotherapy, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Allied Health Professionals Function, Function Area Occupational Therapy & Physiotherapy, Karolinska University Hospital, Stockholm, Sweden.
PLoS One. 2021 May 21;16(5):e0251849. doi: 10.1371/journal.pone.0251849. eCollection 2021.
We investigated the feasibility aspects of two choice reaction time tasks designed to assess implicit sequence learning and dual task ability in individuals with mild to moderate Parkinson's disease in comparison to healthy individuals. Twelve individuals with mild to moderate Parkinson's disease and 12 healthy individuals, all ≥ 60 years of age, were included. A serial reaction time task was used as a measure of implicit sequence learning and a similar task but with the addition of a simple counting task, was used as a measure of dual task ability. We have present thorough descriptive statistics of the data but we have refrained from any inferential statistics due to the small sample size. All participants understood the task instructions and the difficulty level of both tasks was deemed acceptable. There were indications of task fatigue that demand careful choices for how best to analyse the data from such tasks in future trials. Ceiling effects were present in several accuracy outcomes, but not in the reaction time outcomes. Overall, we found both tasks to be feasible to use in samples of individuals with mild to moderate Parkinson's disease and healthy older individuals.
我们研究了两项选择反应时任务的可行性方面，这些任务旨在评估轻度至中度帕金森病患者与健康个体的内隐序列学习和双重任务能力。共纳入 12 名轻度至中度帕金森病患者和 12 名年龄均≥60 岁的健康个体。序列反应时任务用于评估内隐序列学习，而类似的任务但增加了简单的计数任务，用于评估双重任务能力。我们提供了数据的详细描述性统计信息，但由于样本量小，我们避免了任何推论统计。所有参与者都理解任务说明，并且认为两项任务的难度级别都可以接受。有迹象表明存在任务疲劳，因此在未来的试验中需要仔细选择分析此类任务数据的方法。在几个准确性结果中存在天花板效应，但在反应时间结果中没有。总体而言，我们发现这两项任务在轻度至中度帕金森病患者和健康老年人样本中都具有可行性。
