Department of Obstetrics & Gynecology, College of Medicine, Kyung Hee University, Seoul, Korea.
Department of Obstetrics & Gynecology, College of Medicine, Korea University, Seoul, Korea.
PLoS One. 2021 May 21;16(5):e0250659. doi: 10.1371/journal.pone.0250659. eCollection 2021.
The aim of this study was to evaluate the hourly fetal urine production rate (HFUPR) via three-dimensional ultrasonography in women with isolated oligohydramnios and compare with normal pregnant women at term.
This was a prospective observational cohort study of 112 women from 34 to 40 6/7 weeks' gestation. They were classified into three groups according to the amniotic fluid index (AFI) and ultrasonographic estimated fetal weight (EFW) as isolated oligohydramnios (defined as AFI below 5% and appropriate EFW corresponding to gestational age) (n = 34) and IUGR (defined as EFW below 5% corresponding to gestational age irrespective amniotic fluid) (n = 17), and normal pregnancy (n = 61). HFUPR was measured using three-dimensional virtual organ computer-aided analysis. Adverse perinatal outcomes in all participants were examined.
There was no significant difference in HFUPR between patients with isolated oligohydramnios and women with normal pregnancies (median, 40.0 mL/h [interquartile range [IQR] 31.0-66.5] vs. 48.6 [31.5-81.2], p = 0.224). HFUPR was significantly decreased in the IUGR group (13.8 mL/h [IQR 10.1-24.8]), compared to the normal pregnancy group (p<0.001) and the isolated oligohydramnios group (p<0.001). HFUPR was significantly decreased in neonates with adverse perinatal outcomes compared to the control (24.7 mL/h [IQR 13.4-47.4] vs. 43.6 [29.8-79.0], p = 0.016).
HFUPR was not decreased in patients with isolated oligohydramnios but was decreased in patients with IUGR when compared to normal controls at term.
本研究旨在通过三维超声评估单纯性羊水过少孕妇的每小时胎儿尿量生成率（HFUPR），并与足月正常孕妇进行比较。
这是一项前瞻性观察性队列研究，共纳入 112 例孕 34 周至 40 周+6/7 周的孕妇。根据羊水指数（AFI）和超声估计胎儿体重（EFW）将其分为三组：单纯性羊水过少组（AFI<5%，对应胎龄的 EFW 正常）（n=34）、IUGR 组（EFW<5%，对应胎龄的羊水无减少）（n=17）和正常妊娠组（n=61）。使用三维虚拟器官计算机辅助分析测量 HFUPR。所有参与者的不良围产结局均进行了检查。
单纯性羊水过少患者的 HFUPR 与正常妊娠孕妇无显著差异（中位数，40.0 mL/h [四分位距 [IQR] 31.0-66.5] vs. 48.6 [31.5-81.2]，p=0.224）。与正常妊娠组（p<0.001）和单纯性羊水过少组（p<0.001）相比，IUGR 组的 HFUPR 显著降低（13.8 mL/h [IQR 10.1-24.8]）。与对照组相比，不良围产结局新生儿的 HFUPR 显著降低（24.7 mL/h [IQR 13.4-47.4] vs. 43.6 [29.8-79.0]，p=0.016）。
与正常对照组相比，足月时单纯性羊水过少患者的 HFUPR 并未降低，而 IUGR 患者的 HFUPR 则降低。
