Department of Anesthesiology, Shaanxi Provincial Cancer Hospital, Shaanxi, Xi'an, China.
Xi'an 21st Century Biological Sicence and Technology Co., Ltd, Shaanxi, Xi'an, China.
PLoS One. 2021 May 21;16(5):e0252082. doi: 10.1371/journal.pone.0252082. eCollection 2021.
Lung cancer (LC) is a malignant tumor that poses the greatest threat to human health and life. Most studies suggested that the occurrence of LC is associated with environmental and genetic factors. We aimed to explore the association between COL6A4P2 single nucleotide polymorphisms (SNPs) and CHD risk in the Chinese Southern Han population. Based on the 'case-control' experimental design (510 cases and 495 controls), we conducted an association study between five candidate COL6A4P2 SNPs and the corresponding LC risk. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated by logistic regression to analyze the LC susceptibility under different genetic models. The results showed that COL6A4P2 rs34445363 was significantly associated with LC risk under alleles model (OR = 1.26, 95%CI: 1.01-1.58, p = 0.038). In addition, rs34445363 was also significantly associated with LC risk under the log-additive model (OR = 1.26, 95%CI: 1.01-1.58, p = 0.041). The results of subgroup analysis showed that rs34445363 (OR = 1.42, 95%CI: 1.03-1.95, p = 0.033) and rs61733464 (OR = 0.72, 95%CI: 0.52-0.99, p = 0.048) were both significantly associated with LC risk in the log-additive model among participants who were ≤ 61 years old. We also found that the variation of rs34445363 (GA vs. GG, OR = 1.73, 95%CI: 1.04-2.86, p = 0.034) and rs77941834 (TA vs. TT, OR = 1.88, 95%CI: 1.06-3.34, p = 0.032) were associated with LC risk in the codominant model among female participants. Our study is the first to find that COL6A4P2 gene polymorphism is associated with LC risk in the Chinese Han population. Our study provides a basic reference for individualized LC prevention.
肺癌（LC）是对人类健康和生命构成最大威胁的恶性肿瘤。大多数研究表明，LC 的发生与环境和遗传因素有关。我们旨在探讨中国南方汉族人群 COL6A4P2 单核苷酸多态性（SNPs）与 CHD 风险之间的关联。基于“病例对照”实验设计（510 例病例和 495 例对照），我们进行了一项关联研究，以探讨五个候选 COL6A4P2 SNPs 与相应的 LC 风险之间的关系。采用 logistic 回归分析不同遗传模型下 LC 易感性的优势比（OR）和 95%置信区间（CI）。结果表明，COL6A4P2 rs34445363 等位基因模型下与 LC 风险显著相关（OR=1.26，95%CI：1.01-1.58，p=0.038）。此外，rs34445363 在对数加性模型下也与 LC 风险显著相关（OR=1.26，95%CI：1.01-1.58，p=0.041）。亚组分析结果显示，rs34445363（OR=1.42，95%CI：1.03-1.95，p=0.033）和 rs61733464（OR=0.72，95%CI：0.52-0.99，p=0.048）在≤61 岁的参与者中，在对数加性模型下均与 LC 风险显著相关。我们还发现 rs34445363（GA 与 GG，OR=1.73，95%CI：1.04-2.86，p=0.034）和 rs77941834（TA 与 TT，OR=1.88，95%CI：1.06-3.34，p=0.032）在女性参与者的显性模型中与 LC 风险相关。本研究首次发现 COL6A4P2 基因多态性与中国汉族人群 LC 风险相关。本研究为个体化 LC 预防提供了基础参考。
