School of Engineering, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor, Malaysia.
School of Engineering, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor, Malaysia; Advanced Engineering Platform, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor, Malaysia.
Comput Biol Med. 2021 Jul;134:104488. doi: 10.1016/j.compbiomed.2021.104488. Epub 2021 May 14.
Switching bipolar radiofrequency ablation (bRFA) is a cancer treatment technique that activates multiple pairs of electrodes alternately based on a predefined criterion. Various criteria can be used to trigger the switch, such as time (ablation duration) and tissue impedance. In a recent study on time-based switching bRFA, it was determined that a shorter switch interval could produce better treatment outcome than when a longer switch interval was used, which reduces tissue charring and roll-off induced cooling. In this study, it was hypothesized that a more efficacious bRFA treatment can be attained by employing impedance-based switching. This is because ablation per pair can be maximized since there will be no interruption to RF energy delivery until roll-off occurs. This was investigated using a two-compartment 3D computational model. Results showed that impedance-based switching bRFA outperformed time-based switching when the switch interval of the latter is 100 s or higher. When compared to the time-based switching with switch interval of 50 s, the impedance-based model is inferior. It remains to be investigated whether the impedance-based protocol is better than the time-based protocol for a switch interval of 50 s due to the inverse relationship between ablation and treatment efficacies. It was suggested that the choice of impedance-based or time-based switching could ultimately be patient-dependent.
切换双极射频消融（bRFA）是一种癌症治疗技术，它根据预设标准交替激活多对电极。可以使用各种标准来触发切换，例如时间（消融持续时间）和组织阻抗。在最近一项基于时间的切换 bRFA 研究中，确定较短的切换间隔可以比使用较长的切换间隔产生更好的治疗效果，因为这可以减少组织碳化和滚降引起的冷却。在这项研究中，假设采用基于阻抗的切换可以获得更有效的 bRFA 治疗。这是因为在发生滚降之前，不会中断 RF 能量输送，因此可以最大化每对的消融。这是使用两室 3D 计算模型进行的研究。结果表明，当后者的切换间隔为 100 s 或更高时，基于阻抗的切换 bRFA 优于基于时间的切换。与具有 50 s 切换间隔的基于时间的切换相比，基于阻抗的模型性能较差。由于消融和治疗效果之间存在反比关系，因此仍需研究对于 50 s 的切换间隔，基于阻抗的方案是否优于基于时间的方案。有人建议，基于阻抗的或基于时间的切换的选择最终可能取决于患者。
