Macular Disease Research Laboratory, Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China.
Eur J Ophthalmol. 2022 Sep;32(5):NP13-NP19. doi: 10.1177/11206721211015560. Epub 2021 May 21.
To report three cases of Parry-Romberg syndrome (PRS) with progressive hemifacial atrophy and similar fundus changes.
Retrospective case series of three patients who presented to the ophthalmology department with blurred vision in one eye. All of them underwent three-dimensional reconstruction of head computed tomography (CT), related physical examinations, and also monthly ocular examinations of both eyes, including the slit-lamp microscope, fundus autofluorescence, optical coherence tomography (OCT), and fundus fluorescein angiography (FFA). We also reviewed the current literature about the fundus change in PRS from inception to March 2020 via PubMed.
Coats-like fundus and exudative retinal detachment were found in all three eyes of three patients during the follow-up. No systematic changes were found except for hemifacial atrophy. The final diagnoses of these three patients were PRS.
Only a subset of PRS patients have concomitant ocular changes, but it still should be noticed that the diagnosis of PRS should be considered if adults presented with Coats-like retinopathy and hemifacial atrophy.
报告三例进行性半侧颜面萎缩伴相似眼底改变的 Parry-Romberg 综合征（PRS）病例。
回顾性系列病例研究，纳入 3 例因单眼视力模糊就诊于眼科的患者。所有患者均行头部 CT 三维重建、相关体格检查以及每月的双眼眼部检查，包括裂隙灯显微镜、眼底自发荧光、光学相干断层扫描（OCT）和眼底荧光血管造影（FFA）。我们还通过 PubMed 回顾了截至 2020 年 3 月 PRS 眼底改变的现有文献。
在 3 例患者的 3 只眼中，所有患者在随访期间均发现类似 Coats 病的眼底改变和渗出性视网膜脱离。除了半侧颜面萎缩外，未发现其他系统变化。这 3 例患者的最终诊断均为 PRS。
只有一部分 PRS 患者伴有眼部改变，但仍应注意，如果成年人出现类似 Coats 病的视网膜病变和半侧颜面萎缩，应考虑 PRS 的诊断。
