Institute of Pathology, Technical University of Munich, Trogerstr. 18, 81675 Munich, Germany.
Institute of Pathology, Technical University of Munich, Trogerstr. 18, 81675 Munich, Germany.
Clin Lab Med. 2021 Jun;41(2):173-184. doi: 10.1016/j.cll.2021.03.001. Epub 2021 Apr 24.
Mass spectrometry imaging (MSI) combines the excellence in molecular characterization of mass spectrometry with microscopic imaging capabilities of hematoxylin- and eosin-stained samples, enabling the precise location of several analytes in the tissue. Especially in the field of pathology, MSI may have an impactful role in tumor diagnosis, biomarker identification, prognostic prediction, and characterization of tumor margins during tumor resection procedures. This article discusses the recent developments in the field that are paving the way for this technology to become accepted as an analytical tool in the clinical setting, its current limitations, and future directions.
质谱成像（MSI）将质谱在分子特征方面的卓越性能与苏木精和伊红染色样本的微观成像能力相结合，能够精确定位组织中的几种分析物。特别是在病理学领域，MSI 可能在肿瘤诊断、生物标志物识别、预后预测以及肿瘤切除过程中肿瘤边缘的特征刻画方面发挥重要作用。本文讨论了该领域的最新进展，这些进展为该技术成为临床分析工具铺平了道路，同时也探讨了其当前的局限性和未来的发展方向。
