Chamson A, Frey J, Frappaz D, Damon G, Freycon F, Lauras B
Laboratory of Biochemistry, Medical School, Saint-Etienne, France.
Clin Physiol Biochem. 1988;6(2):57-63.
Cells from a skin nodule from a patient with a recurrent form of familial myofibromatosis were cultivated in vitro. A metabolic study showed that these cells behaved like fibroblasts with collagen synthesis, a normal percentage of type III collagen, hydroxylation rate and the ability to contract a collagen gel. The main disturbances were the decreased synthesis and increased cell multiplication rate after a lag phase. This behavior was compared with that of a fibroblast culture from normal skin.
取自一名复发性家族性肌纤维瘤病患者皮肤结节的细胞在体外进行培养。一项代谢研究表明，这些细胞表现得像成纤维细胞，具有胶原蛋白合成能力、正常比例的III型胶原蛋白、羟化率以及收缩胶原凝胶的能力。主要的异常情况是在延迟期后合成减少以及细胞增殖率增加。将这种行为与来自正常皮肤的成纤维细胞培养物的行为进行了比较。
