La Paz University Hospital Health Research Institute, IdiPAZ, Madrid, Spain.
Department of Biochemistry, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), México City, Mexico.
Acta Physiol (Oxf). 2021 Jul;232(3):e13691. doi: 10.1111/apha.13691. Epub 2021 Jun 6.
Ca mishandling is a common feature in several cardiovascular diseases such as heart failure (HF). In many cases, impairment of key players in intracellular Ca homeostasis has been identified as the underlying mechanism of cardiac dysfunction and cardiac arrhythmias associated with HF. In this review, we summarize primary novel findings related to Ca mishandling in HF progression. HF research has increasingly focused on the identification of new targets and the contribution of their role in Ca handling to the progression of the disease. Recent research studies have identified potential targets in three major emerging areas implicated in regulation of Ca handling: the innate immune system, bone metabolism factors and post-translational modification of key proteins involved in regulation of Ca handling. Here, we describe their possible contributions to the progression of HF.
钙处理异常是心力衰竭（HF）等多种心血管疾病的共同特征。在许多情况下，已经确定细胞内钙稳态关键因子的损伤是与 HF 相关的心脏功能障碍和心律失常的潜在机制。在这篇综述中，我们总结了与 HF 进展中钙处理异常相关的主要新发现。HF 研究越来越关注新靶点的鉴定及其在钙处理中的作用对疾病进展的贡献。最近的研究表明，在三个主要的新兴领域中，有一些潜在的靶点与钙处理的调节有关：固有免疫系统、骨代谢因子以及调节钙处理的关键蛋白的翻译后修饰。在这里，我们描述了它们对 HF 进展的可能贡献。
