Shou Jian, Huo Yunlong
Institute of Mechanobiology & Medical Engineering, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
PKU-HKUST Shenzhen-Hong Kong Institution, Shenzhen, Guangdong, China.
Mechanobiol Med. 2023 Jul 5;1(1):100001. doi: 10.1016/j.mbm.2023.100001. eCollection 2023 Sep.
Dysfunctions of calcium cycling occur in heart failure with reduced and preserved ejection fraction (HFrEF and HFpEF). HFrEF and HFpEF showed Ca leakage at diastole. The compensation of Na/Ca exchanger and the decrease of T-tubule density reduces cytoplasmic Ca concentration in HFrEF and impairs systolic function. In contrast, HFpEF has the increase of cytoplasmic Ca concentration and diastolic dysfunctions. The decrease of mitochondrial Ca concentration weakens myocardial contractility in HFrEF while the increased concentration retains the contractility in HFpEF. Here, the changes of calcium cycling in HFrEF and HFpEF are summarized and the possibility of relevant therapeutic targets is discussed.
射血分数降低和保留的心力衰竭（HFrEF和HFpEF）中会出现钙循环功能障碍。HFrEF和HFpEF在舒张期均表现出钙泄漏。钠/钙交换体的代偿作用和T小管密度的降低会降低HFrEF中的细胞质钙浓度并损害收缩功能。相比之下，HFpEF存在细胞质钙浓度升高和舒张功能障碍。线粒体钙浓度降低会削弱HFrEF中的心肌收缩力，而浓度升高则会在HFpEF中维持收缩力。在此，总结了HFrEF和HFpEF中钙循环的变化，并讨论了相关治疗靶点的可能性。
