SARS-CoV-2 B.1.1.7 and B.1.351 spike variants bind human ACE2 with increased affinity.
作者信息
Ramanathan Muthukumar, Ferguson Ian D, Miao Weili, Khavari Paul A
机构信息
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
出版信息
Lancet Infect Dis. 2021 Aug;21(8):1070. doi: 10.1016/S1473-3099(21)00262-0. Epub 2021 May 19.
Abstract
摘要
相似文献
1
SARS-CoV-2 B.1.1.7 and B.1.351 spike variants bind human ACE2 with increased affinity.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的B.1.1.7和B.1.351刺突变异体与人类血管紧张素转换酶2（ACE2）的结合亲和力增强。
Lancet Infect Dis. 2021 Aug;21(8):1070. doi: 10.1016/S1473-3099(21)00262-0. Epub 2021 May 19.
2
Susceptibilities of Human ACE2 Genetic Variants in Coronavirus Infection.人类 ACE2 基因变异体对冠状病毒感染的易感性。
J Virol. 2022 Jan 12;96(1):e0149221. doi: 10.1128/JVI.01492-21. Epub 2021 Oct 20.
3
Angiotensin-Converting Enzyme 2 (ACE2) in the Pathogenesis of ARDS in COVID-19.血管紧张素转换酶 2（ACE2）在 COVID-19 所致急性呼吸窘迫综合征发病机制中的作用。
Front Immunol. 2021 Dec 22;12:732690. doi: 10.3389/fimmu.2021.732690. eCollection 2021.
4
Discovery of human ACE2 variants with altered recognition by the SARS-CoV-2 spike protein.发现人类 ACE2 变体，其与 SARS-CoV-2 刺突蛋白的识别能力改变。
PLoS One. 2021 May 12;16(5):e0251585. doi: 10.1371/journal.pone.0251585. eCollection 2021.
5
The expression of hACE2 receptor protein and its involvement in SARS-CoV-2 entry, pathogenesis, and its application as potential therapeutic target.hACE2 受体蛋白的表达及其在 SARS-CoV-2 进入、发病机制中的作用及其作为潜在治疗靶点的应用。
Tumour Biol. 2021;43(1):177-196. doi: 10.3233/TUB-200084.
6
Quantitative analysis of ACE2 binding to coronavirus spike proteins: SARS-CoV-2 SARS-CoV and RaTG13.定量分析 ACE2 与冠状病毒刺突蛋白的结合：SARS-CoV-2、SARS-CoV 和 RaTG13。
Phys Chem Chem Phys. 2021 Jun 30;23(25):13926-13933. doi: 10.1039/d1cp01075a.
7
Q493K and Q498H substitutions in Spike promote adaptation of SARS-CoV-2 in mice.S 蛋白 493 位和 498 位的 Q 突变为 SARS-CoV-2 在小鼠体内的适应性进化提供了条件。
EBioMedicine. 2021 May;67:103381. doi: 10.1016/j.ebiom.2021.103381. Epub 2021 May 14.
8
SARS-CoV-2 first contact: Spike-ACE2 interactions in COVID-19.SARS-CoV-2 首先接触：COVID-19 中的刺突蛋白-ACE2 相互作用。
Chem Biol Drug Des. 2021 Aug;98(2):207-211. doi: 10.1111/cbdd.13898. Epub 2021 Jun 21.
9
Fast-spreading U.K. virus variant raises alarms.传播迅速的英国病毒变种引发警报。
Science. 2021 Jan 1;371(6524):9-10. doi: 10.1126/science.371.6524.9.
10
Inhibition of SARS-CoV-2 pseudovirus invasion by ACE2 protecting and Spike neutralizing peptides: An alternative approach to COVID19 prevention and therapy.ACE2 保护肽和 Spike 中和肽抑制 SARS-CoV-2 假病毒入侵：COVID19 预防和治疗的另一种方法。
Int J Biol Sci. 2021 Jul 13;17(11):2957-2969. doi: 10.7150/ijbs.61476. eCollection 2021.
引用本文的文献
1
Nanopore sequencing reveals the genomic diversity of the variants of concern of SARS-CoV-2 during 2021 disease outbreak in Pakistan.纳米孔测序揭示了2021年巴基斯坦疾病爆发期间新冠病毒变异株的基因组多样性。
Sci Rep. 2025 Aug 1;15(1):28129. doi: 10.1038/s41598-025-12774-1.
2
Spectroscopic secondary structure fingerprint of β-variant of SARS-CoV-2 spike glycoprotein.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）刺突糖蛋白β变体的光谱二级结构指纹图谱。
Eur Biophys J. 2025 Jul 21. doi: 10.1007/s00249-025-01782-8.
3
Virus-specific host responses and gene signatures following infection with major SARS-CoV-2 variants of concern: role of ZBP1 in viral clearance and lung inflammation.感染主要关注的SARS-CoV-2变异株后的病毒特异性宿主反应和基因特征：ZBP1在病毒清除和肺部炎症中的作用
Front Immunol. 2025 May 9;16:1557535. doi: 10.3389/fimmu.2025.1557535. eCollection 2025.
4
Impact of SARS-CoV-2 RBM Mutations N501Y and E484K on ACE2 Binding: A Combined Computational and Experimental Study.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）受体结合基序（RBM）突变N501Y和E484K对血管紧张素转换酶2（ACE2）结合的影响：一项计算与实验相结合的研究
Int J Mol Sci. 2025 Apr 25;26(9):4064. doi: 10.3390/ijms26094064.
5
PCANN Program for Structure-Based Prediction of Protein-Protein Binding Affinity: Comparison With Other Neural-Network Predictors.基于结构的蛋白质-蛋白质结合亲和力预测的PCANN程序：与其他神经网络预测器的比较
Proteins. 2025 Sep;93(9):1498-1506. doi: 10.1002/prot.26821. Epub 2025 Mar 21.
6
Advancements in Structural Basis of Covalent Inhibitors Targeting SARS-CoV-2 Essential Proteins.靶向严重急性呼吸综合征冠状病毒2（SARS-CoV-2）关键蛋白的共价抑制剂的结构基础研究进展
Curr Med Chem. 2025;32(19):3790-3824. doi: 10.2174/0109298673323348241208080419.
7
High fat, high sucrose diet promotes increased expression of ACE2 receptor in the SIV-infected host: implications for SARS-CoV-2 infection.高脂肪、高蔗糖饮食会促进SIV感染宿主中ACE2受体表达增加：对SARS-CoV-2感染的启示。
Front Nutr. 2024 Sep 30;11:1458106. doi: 10.3389/fnut.2024.1458106. eCollection 2024.
8
Detection and Characterisation of SARS-CoV-2 in Eastern Province of Zambia: A Retrospective Genomic Surveillance Study.赞比亚东部省 SARS-CoV-2 的检测和特征分析：一项回顾性基因组监测研究。
Int J Mol Sci. 2024 Jun 7;25(12):6338. doi: 10.3390/ijms25126338.
9
Genomic characterization of SARS-CoV-2 in Guinea, West Africa.西非几内亚地区的 SARS-CoV-2 基因组特征。
PLoS One. 2024 Mar 6;19(3):e0299082. doi: 10.1371/journal.pone.0299082. eCollection 2024.
10
Mutations in the SARS-CoV-2 spike receptor binding domain and their delicate balance between ACE2 affinity and antibody evasion.SARS-CoV-2 刺突受体结合域的突变及其在与 ACE2 亲和力和抗体逃逸之间的微妙平衡。
Protein Cell. 2024 May 28;15(6):403-418. doi: 10.1093/procel/pwae007.
本文引用的文献
1
Higher infectivity of the SARS-CoV-2 new variants is associated with K417N/T, E484K, and N501Y mutants: An insight from structural data.SARS-CoV-2 新变体的传染性更高与 K417N/T、E484K 和 N501Y 突变有关：来自结构数据的见解。
J Cell Physiol. 2021 Oct;236(10):7045-7057. doi: 10.1002/jcp.30367. Epub 2021 Mar 23.
2
Neutralizing Activity of BNT162b2-Elicited Serum.BNT162b2诱导血清的中和活性
N Engl J Med. 2021 Apr 15;384(15):1466-1468. doi: 10.1056/NEJMc2102017. Epub 2021 Mar 8.
3
SARS-CoV-2 Variants of Concern in the United States-Challenges and Opportunities.美国关注的严重急性呼吸综合征冠状病毒2变种——挑战与机遇
JAMA. 2021 Mar 16;325(11):1037-1038. doi: 10.1001/jama.2021.2294.
4
Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis.去除furin 酶切位点可减轻 SARS-CoV-2 的发病机制。
Nature. 2021 Mar;591(7849):293-299. doi: 10.1038/s41586-021-03237-4. Epub 2021 Jan 25.
5
Spike mutation D614G alters SARS-CoV-2 fitness.刺突突变 D614G 改变了 SARS-CoV-2 的适应性。
Nature. 2021 Apr;592(7852):116-121. doi: 10.1038/s41586-020-2895-3. Epub 2020 Oct 26.
Zotero 插件