前额叶皮层中的 NMDA 受体——突触传递和可塑性的调节。

NMDARs in prefrontal cortex - Regulation of synaptic transmission and plasticity.

机构信息

School of Physiology, Pharmacology and Neuroscience, Biomedical Sciences Building, University Walk, University of Bristol, Bristol BS81TD, UK.

出版信息

Neuropharmacology. 2021 Jul 1;192:108614. doi: 10.1016/j.neuropharm.2021.108614. Epub 2021 May 20.

DOI:10.1016/j.neuropharm.2021.108614

PMID:34022178

Abstract

In this review we consider the various roles played by N-methyl-d-aspartate receptors (NMDARs) located on pyramidal neurones in medial prefrontal cortex (mPFC). We focus on recent data from our lab that has investigated how NMDARs contribute to ongoing synaptic transmission in a frequency dependent manner, the plasticity of NMDARs and how this impacts their contribution to synaptic transmission, and finally consider how NMDARs contribute to plasticity induced by synchronous activation of two separate inputs to mPFC.

摘要

在这篇综述中，我们考虑了位于内侧前额叶皮层（mPFC）的锥体神经元上的 N-甲基-D-天冬氨酸受体（NMDAR）所扮演的各种角色。我们专注于我们实验室的最新数据，该数据研究了 NMDAR 如何以频率依赖的方式促进持续的突触传递、NMDAR 的可塑性以及这如何影响其对突触传递的贡献，最后还考虑了 NMDAR 如何促进来自 mPFC 两个单独输入的同步激活所诱导的可塑性。