Department of Zoology, Pandit Deendayal Upadhyaya Adarsha Mahavidyalaya (PDUAM), Eraligool-788723, Karimganj, Assam, India.
Department of Zoology, Cachar College, Silchar-788001, Assam, India.
Neurochem Int. 2021 Sep;148:105068. doi: 10.1016/j.neuint.2021.105068. Epub 2021 May 20.
7,8-dihydroxyflavone (DHF), a naturally-occurring plant-based flavone, is a high-affinity tyrosine kinase receptor B (TrkB) agonist and a bioactive molecule of therapeutic interest for neuronal survival, differentiation, synaptic plasticity and neurogenesis. In the family of neurotrophic factors, this small BDNF-mimetic molecule has attracted considerable attention due to its oral bioavailability and ability to cross the blood-brain barrier. Recent evidences have shed light on the neuroprotective role of this pleiotropic flavone against several neurological disorders, including Alzheimer's disease, Parkinson's disease, cerebral ischemia, Huntington's disease, and other CNS disorders. DHF also elicits potent protective actions against toxins-induced insults to brain and neuronal cells. DHF shows promising anti-oxidant and anti-inflammatory properties in ameliorating the neurodegenerative processes affecting the CNS. This review provides an overview of the significant neuroprotective potentials of DHF and discusses how it exerts its multitudinous beneficial effects by modulating different pathways linked with the pathophysiology of CNS disorders, and thus proposes it to be a nutraceutical against a broad spectrum of neurological disorders.
7,8-二羟基黄酮（DHF）是一种天然存在的植物类黄酮，是一种高亲和力的酪氨酸激酶受体 B（TrkB）激动剂，也是一种具有治疗潜力的生物活性分子，可促进神经元存活、分化、突触可塑性和神经发生。在神经营养因子家族中，这种与 BDNF 类似的小分子因其口服生物利用度和穿过血脑屏障的能力而引起了相当大的关注。最近的证据表明，这种多效黄酮类化合物对几种神经疾病具有神经保护作用，包括阿尔茨海默病、帕金森病、脑缺血、亨廷顿病和其他中枢神经系统疾病。DHF 还能对抗毒素引起的脑和神经元细胞损伤产生强大的保护作用。DHF 具有有希望的抗氧化和抗炎特性，可改善影响中枢神经系统的神经退行性过程。本综述概述了 DHF 的显著神经保护潜力，并讨论了它如何通过调节与中枢神经系统疾病病理生理学相关的不同途径发挥其多种有益作用，从而提出将其作为一种针对广泛神经疾病的营养保健品。
