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7,8-二羟基黄酮与神经精神障碍：从机制到药物研发的转化视角。

7,8-Dihydroxyflavone and Neuropsychiatric Disorders: A Translational Perspective from the Mechanism to Drug Development.

机构信息

Key Laboratory of Xin'an Medicine, the Ministry of Education, Anhui University of Chinese Medicine, Hefei, Anhui, 230038, China.

出版信息

Curr Neuropharmacol. 2022;20(8):1479-1497. doi: 10.2174/1570159X19666210915122820.

DOI:10.2174/1570159X19666210915122820
PMID:34525922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9881092/
Abstract

7,8-Dihydroxyflavone (7,8-DHF) is a kind of natural flavonoid with the potential to cross the blood-brain barrier. 7,8-DHF effectively mimics the effect of brain-derived neurotrophic factor (BDNF) in the brain to selectively activate tyrosine kinase receptor B (TrkB) and downstream signaling pathways, thus playing a neuroprotective role. The preclinical effects of 7,8-DHF have been widely investigated in neuropsychiatric disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), depression, and memory impairment. Besides the effect on TrkB, 7,8-DHF could also function through fighting against oxidative stress, cooperating with estrogen receptors, or regulating intestinal flora. This review focuses on the recent experimental studies on depression, neurodegenerative diseases, and learning and memory functions. Additionally, the structural modification and preparation of 7,8-DHF were also concluded and proposed, hoping to provide a reference for the follow-up research and clinical drug development of 7,8-DHF in the field of neuropsychiatric disorders.

摘要

7,8-二羟基黄酮（7,8-DHF）是一种具有穿透血脑屏障潜力的天然类黄酮。7,8-DHF 有效地模拟了脑源性神经营养因子（BDNF）在大脑中的作用，选择性地激活酪氨酸激酶受体 B（TrkB）及其下游信号通路，从而发挥神经保护作用。7,8-DHF 在神经精神疾病中的作用已在广泛的临床前研究中得到了研究，包括阿尔茨海默病（AD）、帕金森病（PD）、抑郁症和记忆障碍。除了对 TrkB 的作用外，7,8-DHF 还可以通过对抗氧化应激、与雌激素受体合作或调节肠道菌群发挥作用。本综述重点介绍了 7,8-DHF 在抑郁症、神经退行性疾病和学习记忆功能方面的最新实验研究。此外，还总结和提出了 7,8-DHF 的结构修饰和制备，希望为 7,8-DHF 在神经精神疾病领域的后续研究和临床药物开发提供参考。

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