Soft Tissue and Bone Pathology Section, Department of Pathology, Cleveland Clinic, 9500 Euclid Avenue, L25, Cleveland, OH 44195, USA.
Dermatopathology Section, Department of Pathology, Cleveland Clinic, 9500 Euclid Avenue, L25, Cleveland, OH 44195, USA.
Surg Pathol Clin. 2021 Jun;14(2):195-207. doi: 10.1016/j.path.2021.03.002.
This article focuses on various recently described or emerging cutaneous soft tissue neoplasms. These entities encompass a wide range of clinical and histologic characteristics. Emphasis is placed on their distinguishing morphologic and immunophenotypic features compared with entities that enter into their differential diagnosis, as well as novel immunophenotypic and molecular tests that are often necessary for accurate diagnosis of these entities. Entities discussed include EWSR1-SMAD3-rearranged fibroblastic tumor, superficial CD34-positive fibroblastic tumor, epithelioid fibrous histiocytoma, CIC-rearranged sarcomas, and NTRK-rearranged spindle cell tumors.
本文重点介绍了各种最近描述或新兴的皮肤软组织肿瘤。这些病变涵盖了广泛的临床和组织学特征。本文重点介绍了它们与鉴别诊断相关的形态学和免疫表型特征，以及对于这些病变的准确诊断通常需要的新型免疫表型和分子检测。讨论的病变包括 EWSR1-SMAD3 重排的纤维母细胞瘤、CD34 阳性浅表性纤维母细胞瘤、上皮样纤维组织细胞瘤、CIC 重排肉瘤和 NTRK 重排梭形细胞肿瘤。
