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第五版《世界卫生组织皮肤肿瘤分类》中皮肤间叶肿瘤的更新，重点介绍新的融合相关性肿瘤。

Update on cutaneous mesenchymal tumors in the 5th edition of WHO classification of skin tumors with an emphasis on new fusion-associated neoplasms.

机构信息

Medical Laboratory CSD, Ltd., Kiev, Ukraine.

Department of Pathology, Charles University, Faculty of Medicine in Plzen, Medical Faculty and Charles University Hospital Plzen, Alej Svobody 80, 323 00, Plzen, Czech Republic.

出版信息

Virchows Arch. 2024 Nov;485(5):777-792. doi: 10.1007/s00428-024-03925-2. Epub 2024 Sep 12.

DOI:10.1007/s00428-024-03925-2
PMID:39264472
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11564315/
Abstract

The section on mesenchymal tumors in the 5th edition of WHO classification of skin tumors has undergone several changes, the most important of which is the inclusion of newly identified tumor entities, which will be the main focus of this review article. These specifically include three novel cutaneous mesenchymal tumors with melanocytic differentiation, and rearrangements of the CRTC1::TRIM11, ACTIN::MITF, and MITF::CREM genes as well as EWSR1::SMAD3-rearranged fibroblastic tumors, superficial CD34-positive fibroblastic tumors, and NTRK-rearranged spindle cell neoplasms. Some of the other most important changes will be briefly mentioned as well.

摘要

第五版《世界卫生组织皮肤肿瘤分类》中关于间叶性肿瘤的部分发生了一些变化，其中最重要的是纳入了新确定的肿瘤实体，这将是本文的主要重点。这些实体特别包括三种具有黑色素细胞分化的新型皮肤间叶性肿瘤，以及 CRTC1::TRIM11、ACTIN::MITF 和 MITF::CREM 基因重排以及 EWSR1::SMAD3 重排纤维母细胞瘤、浅表 CD34 阳性纤维母细胞瘤和 NTRK 重排梭形细胞肿瘤。其他一些最重要的变化也将简要提及。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cff/11564315/b69bf4cf3283/428_2024_3925_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cff/11564315/3ab29b90b0fb/428_2024_3925_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cff/11564315/8c56763d532e/428_2024_3925_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cff/11564315/2173e691ee07/428_2024_3925_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cff/11564315/72ffe0a5d074/428_2024_3925_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cff/11564315/b5c994cb5857/428_2024_3925_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cff/11564315/f5c04dd06f8c/428_2024_3925_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cff/11564315/ad8625309a59/428_2024_3925_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cff/11564315/b69bf4cf3283/428_2024_3925_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cff/11564315/3ab29b90b0fb/428_2024_3925_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cff/11564315/8c56763d532e/428_2024_3925_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cff/11564315/2173e691ee07/428_2024_3925_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cff/11564315/72ffe0a5d074/428_2024_3925_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cff/11564315/b5c994cb5857/428_2024_3925_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cff/11564315/f5c04dd06f8c/428_2024_3925_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cff/11564315/ad8625309a59/428_2024_3925_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cff/11564315/b69bf4cf3283/428_2024_3925_Fig8_HTML.jpg

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