Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Surg Pathol Clin. 2021 Jun;14(2):209-224. doi: 10.1016/j.path.2021.01.002. Epub 2021 Apr 28.
Advancements in cancer therapy with monoclonal immune checkpoint antibody blockade have impacted the practice of all medical specialties. Cutaneous immune-related adverse events (irAEs) are a frequent, unintended, off-target consequence of immune checkpoint inhibitor (ICI) therapy that have ushered in the era of oncodermatopathology. Knowledge of the diverse morphologic types of cutaneous irAEs from ICI therapy allows further classification of cutaneous irAEs according to major histopathologic reaction patterns. Early studies suggest that immune mechanisms of lichenoid dermatitis irAE, psoriasiform dermatitis irAE, and bullous pemphigoid irAE show some similarities and differences from their histopathologic counterparts not associated with ICI therapy.
癌症治疗的进展，加上单克隆免疫检查点抗体阻断疗法，已经影响到所有医学专业的实践。皮肤免疫相关不良事件（irAEs）是免疫检查点抑制剂（ICI）治疗的一种常见、非预期的、脱靶的后果，它开创了肿瘤皮肤病理学的时代。了解 ICI 治疗引起的各种形态的皮肤 irAEs，可根据主要组织病理学反应模式对皮肤 irAEs 进行进一步分类。早期研究表明，苔藓样皮炎 irAE、银屑病样皮炎 irAE 和大疱性类天疱疮 irAE 的免疫机制与不与 ICI 治疗相关的组织病理学对照有一些相似和不同之处。
