体力活动与肌萎缩侧索硬化症：孟德尔随机研究。

Physical activity and amyotrophic lateral sclerosis: a Mendelian randomization study.

机构信息

Department of Neurology, Peking University Third Hospital, Beijing, China; Beijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases, Beijing, China.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China; Key Laboratory of Molecular Cardiovascular Sciences, Peking University, Ministry of Education, Beijing, China.

出版信息

Neurobiol Aging. 2021 Sep;105:374.e1-374.e4. doi: 10.1016/j.neurobiolaging.2021.04.010. Epub 2021 Apr 22.

DOI:10.1016/j.neurobiolaging.2021.04.010

PMID:34023151

Abstract

Physical activity (PA) participation has been noted as a potential risk factor for amyotrophic lateral sclerosis (ALS) for decades. However, current studies have been unable to pinpoint the exact relationship between them. Here, we used 2-sample Mendelian randomization (MR), a novel method to systematically investigate causal relationships between PA and ALS. Summary-level data for accelerometer-based and self-reported PA phenotypes were obtained from 2 large genome-wide association studies (GWASs; n = 91,105-377,234), and the ALS summary statistics were from a GWAS of 20,806 cases and 59,804 healthy participants. The present MR study affords no support for causality between 5 included activity habits and ALS. We conclude that PA in the general population is unlikely to affect ALS incidence.

摘要

几十年来，身体活动（PA）参与一直被认为是肌萎缩侧索硬化症（ALS）的一个潜在风险因素。然而，目前的研究还无法确定它们之间的确切关系。在这里，我们使用了两样本 Mendelian randomization（MR），这是一种系统研究 PA 和 ALS 之间因果关系的新方法。加速度计和自我报告的 PA 表型的汇总水平数据来自两项大型全基因组关联研究（GWAS；n=91105-377234），而 ALS 汇总统计数据来自一项 20806 例病例和 59804 例健康参与者的 GWAS。本 MR 研究不支持 5 种活动习惯与 ALS 之间存在因果关系。我们得出结论，普通人群中的 PA 不太可能影响 ALS 的发病率。