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Late Diagnosis of Congenital Toxoplasmosis with Macrocephaly in Dizygotic Twins after Incidental Detection of Leukocoria: A Case Report.迟发性先天性弓形体病伴巨脑畸形的双卵双胎：偶然发现白瞳后的病例报告
J Pediatr. 2021 Sep;236:301-306. doi: 10.1016/j.jpeds.2021.05.040. Epub 2021 May 20.
2
Discordant Congenital Toxoplasmosis and Cytomegalovirus Infection in Dichorionic Diamniotic Twins.双绒双羊型双胞胎的先天性弓形虫病和巨细胞病毒感染不一致。
Pediatr Infect Dis J. 2022 Sep 1;41(9):e377-e382. doi: 10.1097/INF.0000000000003610. Epub 2022 Jul 7.
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Congenital toxoplasmosis in dizygotic twins, Paraná, Brazil.
Rev Inst Med Trop Sao Paulo. 2007 Mar-Apr;49(2):117-8. doi: 10.1590/s0036-46652007000200010.
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[Congenital taxoplasmosis in twins in own material].
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Neurologic and developmental outcome in treated congenital toxoplasmosis.先天性弓形虫病治疗后的神经和发育结局
Pediatrics. 1995 Jan;95(1):11-20.
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Discordant prenatal diagnosis of congenital toxoplasmosis in a dizygotic pregnancy.
Eur J Obstet Gynecol Reprod Biol. 1998 Jul;79(1):107-8. doi: 10.1016/s0301-2115(98)00047-5.
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Late diagnosis of congenital toxoplasmosis based on serological follow-up: A case report.基于血清学随访的先天性弓形虫病迟发诊断：一例报告
Parasitol Int. 2017 Apr;66(2):186-189. doi: 10.1016/j.parint.2016.12.004. Epub 2016 Dec 9.
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Congenital toxoplasmosis in twins: a series of 14 pairs of twins: absence of infection in one twin in two pairs.
J Pediatr. 1976 Aug;89(2):235-40. doi: 10.1016/s0022-3476(76)80455-6.
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Toxoplasmosis: diagnosis, treatment, and prevention in congenitally exposed infants.弓形虫病：先天性感染婴儿的诊断、治疗和预防。
J Pediatr Health Care. 2011 Nov-Dec;25(6):355-64. doi: 10.1016/j.pedhc.2010.04.008. Epub 2010 Jun 12.
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Polymerase chain reaction in cerebrospinal fluid for the diagnosis of congenital toxoplasmosis.脑脊液聚合酶链反应用于先天性弓形虫病的诊断
Pediatr Infect Dis J. 2014 Jun;33(6):566-70. doi: 10.1097/INF.0000000000000256.

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Establishment of a murine model of congenital toxoplasmosis and validation of a qPCR assay to assess the parasite load in maternal and fetal tissues.先天性弓形虫病小鼠模型的建立及用于评估母体和胎儿组织中寄生虫载量的定量聚合酶链反应检测方法的验证
Front Microbiol. 2023 Feb 27;14:1124378. doi: 10.3389/fmicb.2023.1124378. eCollection 2023.
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Building Programs to Eradicate Toxoplasmosis Part I: Introduction and Overview.构建消除弓形虫病的项目 第一部分：引言与概述
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Building Programs to Eradicate Toxoplasmosis Part IV: Understanding and Development of Public Health Strategies and Advances "Take a Village".根除弓形虫病的项目建设 第四部分：公共卫生策略的理解与发展及“以村为单位”的进展
Curr Pediatr Rep. 2022;10(3):125-154. doi: 10.1007/s40124-022-00268-x. Epub 2022 Aug 16.

本文引用的文献

1
Outcomes of hydrocephalus secondary to congenital toxoplasmosis.先天性弓形虫病继发脑积水的结局
J Neurosurg Pediatr. 2019 Sep 6;24(5):601-608. doi: 10.3171/2019.6.PEDS18684. Print 2019 Nov 1.
2
Imaging of congenital central nervous system infections.先天性中枢神经系统感染的影像学检查
Pediatr Radiol. 2018 Apr;48(4):513-523. doi: 10.1007/s00247-018-4092-1. Epub 2018 Mar 17.
3
[DRESS complicated by hemophagocytic lymphohistiocytosis in an infant treated for congenital toxoplasmosis].[先天性弓形虫病治疗的婴儿中伴噬血细胞性淋巴组织细胞增生症的药物疹伴嗜酸性粒细胞增多和系统症状（DRESS）]
Ann Dermatol Venereol. 2017 Dec;144(12):784-787. doi: 10.1016/j.annder.2017.06.004. Epub 2017 Jul 17.
4
Diagnosis, Treatment, and Prevention of Congenital Toxoplasmosis in the United States.美国先天性弓形虫病的诊断、治疗与预防
Pediatrics. 2017 Feb;139(2). doi: 10.1542/peds.2016-3860.
5
Laboratory Diagnosis of Congenital Toxoplasmosis.先天性弓形虫病的实验室诊断
J Clin Microbiol. 2016 Oct;54(10):2448-54. doi: 10.1128/JCM.00487-16. Epub 2016 May 4.
6
Treatment of Congenital Toxoplasmosis: Safety of the Sulfadoxine-Pyrimethamine Combination in Children Based on a Method of Causality Assessment.先天性弓形虫病的治疗：基于因果关系评估方法的儿童磺胺多辛-乙胺嘧啶联合用药安全性研究
Pediatr Infect Dis J. 2016 Jun;35(6):634-8. doi: 10.1097/INF.0000000000001120.
7
Synergistic effect of sulfadiazine and daraprim against experimental toxoplasmosis in the mouse.磺胺嘧啶与达拉匹林对小鼠实验性弓形虫病的协同作用。
Antibiot Chemother (Northfield). 1953 May;3(5):483-90.
8
Congenital toxoplasma infection: monthly prenatal screening decreases transmission rate and improves clinical outcome at age 3 years.先天性弓形虫感染：每月产前筛查可降低 3 岁时的传播率并改善临床结局。
Clin Infect Dis. 2013 May;56(9):1223-31. doi: 10.1093/cid/cit032. Epub 2013 Jan 29.
9
Severe congenital toxoplasmosis in the United States: clinical and serologic findings in untreated infants.美国严重先天性弓形虫病：未经治疗婴儿的临床和血清学发现。
Pediatr Infect Dis J. 2011 Dec;30(12):1056-61. doi: 10.1097/INF.0b013e3182343096.
10
Ocular manifestations of congenital toxoplasmosis.先天性弓形虫病的眼部表现。
Eye (Lond). 2010 Apr;24(4):528-34. doi: 10.1038/eye.2009.140. Epub 2009 Jun 12.

迟发性先天性弓形体病伴巨脑畸形的双卵双胎：偶然发现白瞳后的病例报告

Late Diagnosis of Congenital Toxoplasmosis with Macrocephaly in Dizygotic Twins after Incidental Detection of Leukocoria: A Case Report.

机构信息

Division of Infectious Diseases, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA.

Dr Jack S. Remington Laboratory for Specialty Diagnostics, National Reference Center for the Study and Diagnosis of Toxoplasmosis Palo Alto Medical Foundation, Palo Alto, CA.

出版信息

J Pediatr. 2021 Sep;236:301-306. doi: 10.1016/j.jpeds.2021.05.040. Epub 2021 May 20.

DOI:10.1016/j.jpeds.2021.05.040
PMID:34023345
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9642312/
Abstract

Untreated congenital toxoplasmosis remains an important cause of neurologic and ocular disease worldwide. However, congenitally infected infants may not have signs and symptoms their physicians recognize, leading to delayed diagnosis and missed opportunities for treatment. We describe a pair of twins diagnosed with congenital toxoplasmosis at 11 months of age following incidental detection of leukocoria in one twin.

摘要

未经治疗的先天性弓形虫病仍然是全世界导致神经和眼部疾病的一个重要原因。然而，先天性感染的婴儿可能没有其医生能够识别的体征和症状，导致诊断延迟和错失治疗机会。我们描述了一对双胞胎，在其中一个双胞胎偶然发现白瞳后，于 11 个月大时被诊断出患有先天性弓形虫病。