Light Kelly, Karboune Salwa
Department of Food Science and Agricultural Chemistry, McGill University, Sainte-Anne-de-Bellevue, Canada.
Crit Rev Food Sci Nutr. 2022;62(29):8199-8229. doi: 10.1080/10408398.2021.1926903. Epub 2021 May 22.
Emulsions, hydrogels and emulgels have attracted a high interest as tools for the delivery of poorly soluble hydrophobic nutraceuticals by enhancing their stability and bioavailability. This review provides an overview of these delivery systems, their unique qualities and their interactions with the human gastrointestinal system. The modulation of the various delivery systems to enhance the bioavailability and modify the release profile of bioactive encapsulates is highlighted. The application of the delivery systems in the delivery of cannabinoids is also discussed. With the recent increase of cannabis legalization across North America, there is much interest in developing cannabis edibles which can provide a consistent dose of cannabinoids per portion with a rapid time of onset. Indeed, the long time of onset of psychoactive effects and varied metabolic responses to these products result in a high risk of severe intoxication due to overconsumption. Sophisticated emulsion or hydrogel-based delivery systems are one potential tool to achieve this goal. To date, there is a lack of evidence linking specific classes of delivery systems with their pharmacokinetic profiles in humans. More research is needed to directly compare different classes of delivery systems for the gastrointestinal delivery of cannabinoids.
乳液、水凝胶和乳化凝胶作为提高难溶性疏水性营养保健品稳定性和生物利用度的递送工具，已引起了广泛关注。本文综述了这些递送系统、它们的独特性质以及它们与人体胃肠道系统的相互作用。重点介绍了各种递送系统的调控，以提高生物利用度并改变生物活性包封物的释放曲线。还讨论了递送系统在大麻素递送中的应用。随着北美近期大麻合法化的增加，人们对开发大麻食品产生了浓厚兴趣，这些食品每份能提供一致剂量的大麻素，且起效迅速。事实上，精神活性作用起效时间长以及对这些产品的代谢反应各异，导致因过量食用而出现严重中毒的风险很高。复杂的基于乳液或水凝胶的递送系统是实现这一目标的一种潜在工具。迄今为止，缺乏证据将特定类型的递送系统与其在人体中的药代动力学特征联系起来。需要更多研究来直接比较不同类型的递送系统用于大麻素的胃肠道递送。
