Jamshaid Usama, Anton Nicolas, Elhassan Mohamed, Conzatti Guillaume, Vandamme Thierry F
INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine (RNM), FMTS, Université de Strasbourg, F-67000 Strasbourg, France.
Faculty of Pharmacy, The University of Lahore, Lahore 54590, Pakistan.
Pharmaceutics. 2024 Jun 14;16(6):812. doi: 10.3390/pharmaceutics16060812.
In this study, we present a new type of polymer-free hydrogel made only from nonionic surfactants, oil, and water. Such a system is produced by taking advantage of the physicochemical behavior and interactions between nonionic surfactants and oil and water phases, according to a process close to spontaneous emulsification used in the production of nano-emulsions. Contrary to the classical process of emulsion-based gel formulation, we propose a simple one-step approach. Beyond the originality of the concept, these appear as very promising systems able to encapsulate and deliver various molecules with different solubilities. In the first section, we propose a comprehensive investigation of the gel formation process and its limits through oscillatory rheological characterization, characterization of the sol/gel transitions, and gel strength. The second section is focused on the follow-up of the release of an encapsulated model hydrophilic molecule and on the impact of the rheological gel properties on the release profiles.
在本研究中，我们展示了一种仅由非离子表面活性剂、油和水制成的新型无聚合物水凝胶。这种体系是利用非离子表面活性剂与油相和水相之间的物理化学行为及相互作用来制备的，其过程类似于纳米乳液生产中使用的自发乳化过程。与基于乳液的凝胶配方的经典过程不同，我们提出了一种简单的一步法。除了概念的创新性之外，这些体系似乎是非常有前景的，能够封装和递送具有不同溶解度的各种分子。在第一部分中，我们通过振荡流变学表征、溶胶/凝胶转变的表征以及凝胶强度，对凝胶形成过程及其极限进行了全面研究。第二部分重点关注封装的模型亲水分子的释放过程以及流变凝胶性质对释放曲线的影响。
