Emmrich F, Keitel R, Sorger K, Otto U, Staffa G, Klötzer B
Exp Pathol (Jena). 1977;14(6):334-9. doi: 10.1016/s0014-4908(77)80053-7.
The variation of immune serum globulin concentrations in 14 pigs was determined after unilateral allogenic renal transplantation. Measures by which it is possible to exert certain immunological influences were not taken. Subsequent to transplantation there was observed a significant decrease in both IgM and IgG which was not correlated with the behaviour of plasma proteins and albumin. Because of the relatively small loss of IgG in the urine of animals on which transplantations were performed, this cannot be considered to be the cause of the decrease in immunoglobulin. It was already on the 3rd day after transplantation that an increase in IgM was observed which after reaching a peak of about + 30% was again followed by a distinct decrease of which the minimum was noted between the 6th and 15th days after transplantation. 10 animals died within the first phase, and in 4 of them death occurred on account of rejection for which histological evidence could be obtained. Although 3 of the 4 animals surviving for a longer period of time were also observed to suffer from distinct rejective crises between the 8th and 15th day after transplantation, they were able to overcome those crises without any therapeutical intervention. After some time, however, they were experiencing another IgM peak (this time greater than + 80%) which was followed, after 3 to 11 days, but the final crisis of rejection and death of the animal. In a few cases, glomerular IgM deposits were found in transplanted kidneys.
对14头猪进行单侧同种异体肾移植后，测定了其免疫血清球蛋白浓度的变化。未采取能够施加特定免疫影响的措施。移植后观察到IgM和IgG均显著下降，这与血浆蛋白和白蛋白的变化无关。由于进行移植的动物尿液中IgG损失相对较小，因此不能认为这是免疫球蛋白下降的原因。移植后第3天就观察到IgM增加，在达到约+30%的峰值后又明显下降，在移植后第6天至第15天之间降至最低。10只动物在第一阶段死亡，其中4只因排斥反应死亡，可获得组织学证据。虽然在移植后第8天至第15天之间，4只存活较长时间的动物中有3只也出现了明显的排斥危机，但它们在没有任何治疗干预的情况下克服了这些危机。然而，一段时间后，它们又出现了另一个IgM峰值（这次大于+80%），在3至11天后，动物出现了最终的排斥危机并死亡。在少数情况下，在移植肾中发现了肾小球IgM沉积。
