牛磺酸和含咖啡因能量饮料摄入后脉络膜厚度变化的研究。
Study of choroidal thickness variations after ingestion of a taurine and caffeine-containing energy drink.
机构信息
Department of Ophthalmology (vitreoretinal Department), Rothschild Foundation Hospital, 29 Rue Manin, 75019 Paris, France; Department of Clinical Research, Rothschild Foundation Hospital, 29 Rue Manin, 75019 Paris, France.
Department of Clinical Research, Rothschild Foundation Hospital, 29 Rue Manin, 75019 Paris, France; Department of Ophthalmology (anterior Segment Department), Rothschild Foundation Hospital, 29 Rue Manin, 75019 Paris, France.
出版信息
Clin Nutr ESPEN. 2021 Jun;43:245-249. doi: 10.1016/j.clnesp.2021.04.007. Epub 2021 Apr 17.
BACKGROUND & AIMS: Choroidal thickness can undergo considerable variations in response to different substances. The aim of this study was to assess the change in choroidal thickness after the ingestion of taurine and caffeine contained in the Red Bull energy drink.
METHODS
Enhanced Depth Imaging - Spectral Domain Optical Coherence Tomography was used to measure subfoveal choroidal thickness (SFCT) variations in healthy volunteers at several time points after drinking a Red Bull can (25 cl).
RESULTS
Forty eyes of 20 volunteers were enrolled. A significant reduction in SFCT (-14 μm, p < 0.0001) occurred at 1 h after the Red Bull intake, and was even more important (-20.14 μm, p < 0.0001) in eyes with particularly thick choroids (≥ 395 μm). SFCT measurements at 4 h were comparable to baseline.
CONCLUSIONS
A concomitant ingestion of caffeine and taurine can induce a transient choroidal thinning that is more marked in eyes with thick choroids.
REGISTRATION NUMBER OF CLINICAL TRIAL
NCT02856256.
背景与目的
脉络膜厚度会因不同物质而发生明显变化。本研究旨在评估红牛能量饮料中所含牛磺酸和咖啡因摄入后脉络膜厚度的变化。
方法
使用增强深度成像-光谱域光相干断层扫描（EDI-SDOCT）在饮用红牛罐（25cl）后的多个时间点测量健康志愿者的中心凹下脉络膜厚度（SFCT）变化。
结果
共纳入 20 名志愿者的 40 只眼。红牛摄入后 1 小时 SFCT 显著减少（-14μm，p<0.0001），在脉络膜特别厚（≥395μm）的眼中更为明显（-20.14μm，p<0.0001）。4 小时的 SFCT 测量值与基线值相当。
结论
同时摄入咖啡因和牛磺酸可引起短暂的脉络膜变薄，在脉络膜较厚的眼中更为明显。
临床试验注册号
NCT02856256。
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