Department of Radiology, Tianjin First Central Hospital, No. 24, Fukang Road, Nankai District, Tianjin, 300000, China.
Outpatient Department, Tianjin Third Central Hospital, No. 83, Jintang Road, Hedong District, Tianjin, 300000, China.
Clin Radiol. 2021 Aug;76(8):628.e9-628.e15. doi: 10.1016/j.crad.2021.04.002. Epub 2021 May 20.
To assess systematically the prognostic value of cardiac magnetic resonance imaging (CMRI) in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC).
The full text of studies of the clinical efficacy of late gadolinium enhancement (LGE) in ARVC was retrieved in multiple databases. Stata 14 was adopted for meta-analysis and bias analysis. Heterogeneity was assessed with the I statistic.
After exclusions, 561 patients were included in five studies, and the eligibility criteria were met. The meta-analysis suggested that there was a significant difference between LGE positive and negative patients with ARVC in all-cause mortality (relative risk [RR] = 4.78, 95% confidence interval [CI] = 1.41, 16.23, p=0.012; p for heterogeneity = 0.692, I = 0%); major adverse cardiovascular events (MACE) (RR=2.48, 95% CI = 1.24, 4.96, p=0.010; p for heterogeneity = 0.596, I = 0%); ventricular tachycardia (RR=3.13, 95% CI = 1.69, 5.78, p<0.001; p for heterogeneity = 0.825, I = 0%); implanted cardiac defibrillators (RR=3.15, 95% CI = 1.69, 5.87], p<0.001; p for heterogeneity = 0.353, I = 9.4%).
LGE in ARVC patients is a predictor of all-cause mortality and MACE.
系统评估心脏磁共振成像（CMRI）在致心律失常性右室心肌病（ARVC）患者中的预后价值。
在多个数据库中检索 ARVC 中晚期钆增强（LGE）临床疗效的研究全文。采用 Stata 14 进行荟萃分析和偏倚分析。采用 I 统计量评估异质性。
排除后，5 项研究共纳入 561 例患者，符合纳入标准。荟萃分析提示 ARVC 患者中 LGE 阳性与阴性患者在全因死亡率（相对危险度 [RR] = 4.78，95%置信区间 [CI] = 1.4116.23，p = 0.012；p 异质性 = 0.692，I = 0%）、主要不良心血管事件（MACE）（RR = 2.48，95%CI = 1.244.96，p = 0.010；p 异质性 = 0.596，I = 0%）、室性心动过速（RR = 3.13，95%CI = 1.695.78，p<0.001；p 异质性 = 0.825，I = 0%）和植入式心脏除颤器（RR = 3.15，95%CI = 1.695.87，p<0.001；p 异质性 = 0.353，I = 9.4%）方面差异均有统计学意义。
ARVC 患者的 LGE 是全因死亡率和 MACE 的预测因子。
