Research Institute of General Surgery, Jinling Hospital, School of Medicine, Southeast University, Nanjing, China 210009.
Research Institute of General Surgery, Jinling Hospital, School of Medicine, Southeast University, Nanjing, China 210009.
Trends Cell Biol. 2021 Jul;31(7):517-519. doi: 10.1016/j.tcb.2021.05.002. Epub 2021 May 20.
Given the mismatch in size and morphology of intestinal organoids with native intestine, their application in intestinal segment regeneration has yet to be achieved. By engrafting ileal organoids in epithelium-removed colon, Sugimoto et al. recently constructed transplantable colonic segments with functional ileal epithelium and a subepithelial lymphovascular system, providing hope for the treatment of short bowel syndrome.
鉴于肠类器官的大小和形态与天然肠道不匹配，它们在肠道节段再生中的应用尚未实现。最近，Sugimoto 等人通过将回肠类器官植入去除上皮的结肠中，构建了具有功能性回肠上皮和黏膜下淋巴血管系统的可移植结肠节段，为短肠综合征的治疗提供了希望。
