Baker B J, Duggan J P, Barber D J, Booth D A
Department of Psychology, University of Birmingham, England.
Eur J Pharmacol. 1988 May 20;150(1-2):137-42. doi: 10.1016/0014-2999(88)90759-5.
Freely feeding rats received an anorexigenic dose of dl-fenfluramine HCl (5 mg/kg). Two hours following injection, their stomachs retained significantly greater dry weight contents than saline-injected controls. The same dose of fenfluramine decreased the rate of gastric emptying over a 2 h period to a similar extent in mildly food-deprived rats. The peripherally acting serotonin antagonist xylamidine counteracted the effect of fenfluramine in prolonging the satiating effect of an ad libitum meal of a given size. We propose therefore that the principal mechanism by which fenfluramine reduces food consumption in freely feeding rats is through a prolongation of the satiating effect of absorption as a result of slowing of gastric emptying, presumably via enhanced release of serotonin from nerve terminals in the wall of the gastrointestinal tract.
自由进食的大鼠接受了致厌食剂量的盐酸右芬氟拉明（5毫克/千克）。注射后两小时，它们胃中保留的干重内容物明显多于注射生理盐水的对照组。相同剂量的芬氟拉明在轻度饥饿的大鼠中，在2小时内使胃排空率下降到相似程度。外周作用的5-羟色胺拮抗剂赛拉米定抵消了芬氟拉明延长给定大小随意进食餐的饱腹感的作用。因此，我们认为芬氟拉明减少自由进食大鼠食物摄入量的主要机制是通过减缓胃排空，可能是通过增强胃肠道壁神经末梢5-羟色胺的释放，从而延长吸收的饱腹感。
