Ludatscher R M, Silbermann M
Department of Pathology, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
Exp Gerontol. 1988;23(2):127-37. doi: 10.1016/0531-5565(88)90077-0.
Intramuscular branches of tibial nerves of 5- and 27-month-old mice were compared. Seventeen intramuscular nerve fascicles were studied in each group: 174 myelinated axons were evaluated in the young mice, and 136 in the aged mice. The old mice showed significant decreases in numbers of myelinated axons per nerve, and these had significant decreases in concentrations of mitochondria. Interaxonal collagen and numbers of collagen fibrils were increased, as was the concentration of unmyelinated axons. Myelinated axons of old mice demonstrated myelin disorganization, myelin nodules, degeneration of axoplasm and Schwann cells.
对5月龄和27月龄小鼠的胫神经肌内分支进行了比较。每组研究17个肌内神经束：在年轻小鼠中评估了174条有髓轴突，在老年小鼠中评估了136条。老年小鼠每条神经的有髓轴突数量显著减少，并且这些轴突的线粒体浓度也显著降低。轴突间胶原蛋白和胶原纤维数量增加，无髓轴突浓度也增加。老年小鼠的有髓轴突表现出髓鞘紊乱、髓鞘结节、轴浆和施万细胞变性。
