Ding Ya-Hui, Qian Lin-Yan, Pang Jie, Lin Jing-Yang, Xu Qiang, Wang Li-Hong, Huang Dong-Sheng, Zou Hai
Department of Cardiology, Zhejiang Provincial People's Hospital, Hangzhou 310014, Chinaa.
People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.
Oncotarget. 2017 Jun 2;8(35):59915-59928. doi: 10.18632/oncotarget.18346. eCollection 2017 Aug 29.
Atherosclerosis is an inflammatory disease regulated by several immune cells including lymphocytes, macrophages and dendritic cells. Gut probiotic bacteria like have been shown immunomodificatory effects in the progression of atherogenesis. Some stains can upregulate the activity of regulatory T-lymphocytes, suppress T-lymphocyte helper (Th) cells Th1, Th17, alter the Th1/Th2 ratio, influence the subsets ratio of M1/M2 macrophages, inhibit foam cell formation by suppressing macrophage phagocytosis of oxidized low-density lipoprotein, block the activation of the immune system with dendritic cells, which are expected to suppress the atherosclerosis-related inflammation. However, various strains can have various effects on inflammation. Some other strains were found have potential pro-atherogenic effect through promote Th1 cell activity, increase pro-inflammatory cytokines levels as well as decrease anti-inflammatory cytokines levels. Thus, identifying the appropriate strains is essential to the therapeutic potential of as an anti-atherosclerotic therapy.
动脉粥样硬化是一种由包括淋巴细胞、巨噬细胞和树突状细胞在内的多种免疫细胞调节的炎症性疾病。肠道益生菌如已被证明在动脉粥样硬化发生发展过程中具有免疫调节作用。一些菌株可以上调调节性T淋巴细胞的活性，抑制T淋巴细胞辅助细胞Th1、Th17，改变Th1/Th2比值，影响M1/M2巨噬细胞的亚群比例，通过抑制巨噬细胞对氧化型低密度脂蛋白的吞噬作用来抑制泡沫细胞形成，阻断树突状细胞对免疫系统的激活，有望抑制动脉粥样硬化相关炎症。然而，不同的菌株对炎症可能有不同的影响。还发现一些其他菌株通过促进Th1细胞活性、增加促炎细胞因子水平以及降低抗炎细胞因子水平而具有潜在的促动脉粥样硬化作用。因此，确定合适的菌株对于作为抗动脉粥样硬化疗法的治疗潜力至关重要。
