Lee Byeong-Jae, Min Chan-Ki, Hancock Meaghan, Streblow Daniel N, Caposio Patrizia, Goodrum Felicia D, Yurochko Andrew D
Department of Microbiology & Immunology, Center for Molecular and Tumor Virology, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, United States.
Center for Applied Immunology and Pathological Processes, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, United States.
Front Microbiol. 2021 May 7;12:660901. doi: 10.3389/fmicb.2021.660901. eCollection 2021.
Viruses have evolved diverse strategies to manipulate cellular signaling pathways in order to promote infection and/or persistence. Human cytomegalovirus (HCMV) possesses a number of unique properties that allow the virus to alter cellular events required for infection of a diverse array of host cell types and long-term persistence. Of specific importance is infection of bone marrow derived and myeloid lineage cells, such as peripheral blood monocytes and CD34 hematopoietic progenitor cells (HPCs) because of their essential role in dissemination of the virus and for the establishment of latency. Viral induced signaling through the Epidermal Growth Factor Receptor (EGFR) and other receptors such as integrins are key control points for viral-induced cellular changes and productive and latent infection in host organ systems. This review will explore the current understanding of HCMV strategies utilized to hijack cellular signaling pathways, such as EGFR, to promote the wide-spread dissemination and the classic life-long herpesvirus persistence.
病毒已经进化出多种策略来操纵细胞信号通路，以促进感染和/或持续存在。人类巨细胞病毒（HCMV）具有许多独特的特性，使该病毒能够改变感染多种宿主细胞类型和长期持续存在所需的细胞事件。特别重要的是骨髓来源的和髓系谱系细胞的感染，例如外周血单核细胞和CD34造血祖细胞（HPCs），因为它们在病毒传播和潜伏建立中起着至关重要的作用。通过表皮生长因子受体（EGFR）和其他受体（如整合素）的病毒诱导信号传导是病毒诱导的细胞变化以及宿主器官系统中 productive 和潜伏感染的关键控制点。本综述将探讨目前对HCMV用于劫持细胞信号通路（如EGFR）以促进广泛传播和经典的终身疱疹病毒持续存在的策略的理解。
