输尿管肿瘤与肾盂肾盏肿瘤患者的生存差异：一项系统评价和荟萃分析。
Survival differences of patients with ureteral versus pelvicalyceal tumours: a systematic review and meta-analysis.
作者信息
Kaczmarek Krystian, Lemiński Artur, Gołąb Adam, Słojewski Marcin
机构信息
Department of Urology and Urological Oncology, Pomeranian Medical University, Szczecin, Poland.
出版信息
Arch Med Sci. 2019 Nov 21;17(3):603-612. doi: 10.5114/aoms.2019.89893. eCollection 2021.
INTRODUCTION
Worse survival in upper tract urothelial carcinoma (UTUC) in the presence of a tumour in the ureter vs. pelvicalyceal tumours is reported in some studies; however, the definition of ureteral involvement (UI) varies across studies. We systematically evaluated evidence regarding the prognostic role of UI in overall and cancer-specific survival of patients with UTUC.
MATERIAL AND METHODS
A systematic search of PubMed, Scopus and Web of Knowledge was performed in March 2018.
RESULTS
The results were presented as a comparison between ureteral vs. pelvicalyceal tumours. A total of 14,895 patients were identified. Cumulative analyses indicated that UI worsens cancer-specific survival (CSS) and overall survival (OS), with a pooled HR of 1.52 ( < 0.001) and 1.39 ( = 0.004), respectively.
CONCLUSIONS
Our meta-analysis identified UI in UTUC as an adverse prognostic factor.
引言
一些研究报告称，输尿管存在肿瘤的上尿路尿路上皮癌（UTUC）患者的生存率低于肾盂肿瘤患者；然而，各研究中输尿管受累（UI）的定义有所不同。我们系统地评估了关于UI对UTUC患者总生存和癌症特异性生存的预后作用的证据。
材料与方法
2018年3月对PubMed、Scopus和Web of Knowledge进行了系统检索。
结果
结果以输尿管肿瘤与肾盂肿瘤的比较形式呈现。共识别出14895例患者。累积分析表明，UI会使癌症特异性生存（CSS）和总生存（OS）恶化，合并风险比分别为1.52（<0.001）和1.39（=0.004）。
结论
我们的荟萃分析确定UTUC中的UI是一个不良预后因素。
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