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一项关于使用游离髂骨瓣进行下颌骨重建的回顾性研究。

A retrospective study on mandibular reconstruction using iliac crest free flap.

作者信息

Garajei Ata, Kheradmand Ali A, Miri Seyed Roohollah, Emami Azadeh

机构信息

Department of Oral and Maxillofacial Surgery, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

The Cancer Institute, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Ann Med Surg (Lond). 2021 May 5;66:102354. doi: 10.1016/j.amsu.2021.102354. eCollection 2021 Jun.

Abstract

PURPOSE

To assess the availability, success rate and complications of microvascular iliac crest free flap for reconstruction of mandibular segmental defects.

METHODS

In this retrospective-descriptive study, we report patients who had undergone segmental mandibular resection for pathologic lesions and received reconstruction with iliac crest microvascular free flap between 2016 and 2019. Clinical and demographic data of all the cases were collected. Success was regarded as complete consolidation of the bone graft in panoramic radiograph. Postoperative complications were defined as major or minor based on the need for intervention. T-test, Kolomogorov_Smirnov, and multivariate analysis were used and the p-value<0.05 was considered to be statistically significant.

RESULTS

Of all 30 patients, 16 were women and 14 were men with an average age of 27.2 years (range 14-40). Patients were followed for 12-60 month (mean: 38.4). One flap was lost due to unsalvageable venous thrombosis. Six other cases had post-op complications while smoking and diabetes were associated with more complications (P = 0.036). Twenty-three patients received primary reconstruction which was more successful than secondary ones (P = 0.003). Osteogenic sarcoma was associated with greater risk of complications (P < 0.01).

CONCLUSIONS

The results of this study suggest that iliac crest microvascular free flap serves as a promising option for the reconstruction of mandibular defects, providing excellent contour and acceptable success rate with low donor site morbidity. Future studies will focus on the role of systemic diseases in post-op complications and flap failures.

摘要

目的

评估微血管游离髂骨瓣修复下颌骨节段性缺损的可行性、成功率及并发症。

方法

在这项回顾性描述性研究中,我们报告了2016年至2019年间因病理性病变接受下颌骨节段性切除并采用微血管游离髂骨瓣进行修复的患者。收集了所有病例的临床和人口统计学数据。在全景X线片上,骨移植完全愈合视为成功。根据是否需要干预将术后并发症分为严重或轻微。采用t检验、柯尔莫哥洛夫-斯米尔诺夫检验和多变量分析,p值<0.05被认为具有统计学意义。

结果

30例患者中,女性16例,男性14例,平均年龄27.2岁(范围14 - 40岁)。患者随访12 - 60个月(平均38.4个月)。1例皮瓣因无法挽救的静脉血栓形成而丢失。另外6例有术后并发症,吸烟和糖尿病与更多并发症相关(P = 0.036)。23例患者接受一期修复,其成功率高于二期修复(P = 0.003)。骨肉瘤患者并发症风险更高(P < 0.01)。

结论

本研究结果表明,微血管游离髂骨瓣是修复下颌骨缺损的一个有前景的选择,能提供良好的外形,成功率可接受,供区并发症发生率低。未来研究将聚焦全身性疾病在术后并发症和皮瓣失败中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d075/8121997/358fe8d590b2/gr1.jpg

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