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卵巢莱迪希细胞瘤引起的高雄激素血症、月经过少和红细胞增多症：一例报告

Hyperandrogenism, oligomenorrhea, and erythrocytosis caused by an ovarian Leydig cell tumor: A case report.

作者信息

Mendonça Fernando, Souto Selma, Magalhães Daniela, Portugal Raquel, Coelho Ana Rita, Fernandes Ana Sofia, Falcão Vera, Tavares Sara, Portugal Inês, Beires Jorge, Carvalho Davide

机构信息

Serviço de Endocrinologia Diabetes e Metabolismo Centro Hospitalar e Universitário de S. João Porto Portugal.

Faculdade de Medicina da Universidade do Porto Porto Portugal.

出版信息

Clin Case Rep. 2021 Mar 26;9(5):e04001. doi: 10.1002/ccr3.4001. eCollection 2021 May.

DOI:10.1002/ccr3.4001
PMID:34026130
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8117810/
Abstract

Leydig cell tumors are rare ovarian neoplasms. Affected individuals typically present with amenorrhea/oligomenorrhea and rapidly progressive features of virilization. Erythrocytosis can also occur as a result of high testosterone levels.

摘要

睾丸间质细胞瘤是一种罕见的卵巢肿瘤。受影响的个体通常表现为闭经/月经过少以及迅速进展的男性化特征。红细胞增多症也可能由于高睾酮水平而发生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f46a/8117810/64ee4d52a0f3/CCR3-9-e04001-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f46a/8117810/64ee4d52a0f3/CCR3-9-e04001-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f46a/8117810/64ee4d52a0f3/CCR3-9-e04001-g001.jpg

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1
Hyperandrogenism, oligomenorrhea, and erythrocytosis caused by an ovarian Leydig cell tumor: A case report.卵巢莱迪希细胞瘤引起的高雄激素血症、月经过少和红细胞增多症：一例报告
Clin Case Rep. 2021 Mar 26;9(5):e04001. doi: 10.1002/ccr3.4001. eCollection 2021 May.
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[Sertoli-Leydig cell tumour (arrhenoblastoma) in a patient with polycystic ovary syndrome: clinical, ultrasonographic, hormonal and histopathological evaluation].[多囊卵巢综合征患者的支持-间质细胞瘤（男性细胞瘤）：临床、超声、激素及组织病理学评估]
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本文引用的文献

1
Diagnosis of a small Leydig cell tumor by dynamic contrast-enhanced and diffusion-weighted magnetic resonance imaging.通过动态对比增强和扩散加权磁共振成像诊断小的莱迪希细胞瘤
Radiol Case Rep. 2020 May 1;15(7):875-878. doi: 10.1016/j.radcr.2020.04.019. eCollection 2020 Jul.
2
Ovarian Steroid Cell Tumor in an Adolescent With Von Hippel-Lindau Syndrome: A Case Report and Review of the Literature.青少年 von Hippel-Lindau 综合征合并卵巢类固醇细胞瘤 1 例报告并文献复习
Int J Gynecol Pathol. 2020 Sep;39(5):473-477. doi: 10.1097/PGP.0000000000000628.
3
An ovarian Leydig cell tumor of ultrasound negative in a postmenopausal woman with hirsutism and hyperandrogenism: A case report.
一名绝经后多毛症和高雄激素血症女性患者的超声检查阴性的卵巢莱迪希细胞瘤：病例报告
Medicine (Baltimore). 2018 Mar;97(10):e0093. doi: 10.1097/MD.0000000000010093.
4
Ovarian Leydig cell tumor in a post-menopausal patient with severe hyperandrogenism.一名绝经后严重高雄激素血症患者的卵巢莱迪希细胞瘤。
Arq Bras Endocrinol Metabol. 2014 Feb;58(1):68-75. doi: 10.1590/0004-2730000002461.
5
A Leydig cell tumor of the ovary resulting in extreme hyperandrogenism, erythrocytosis, and recurrent pulmonary embolism.卵巢的睾丸间质细胞瘤导致严重的高雄激素血症、红细胞增多症和复发性肺栓塞。
J Clin Endocrinol Metab. 2014 Jan;99(1):12-7. doi: 10.1210/jc.2013-3108. Epub 2013 Dec 20.
6
Impact of clinical, hormonal, radiological, and immunohistochemical studies on the diagnosis of postmenopausal hyperandrogenism.绝经后高雄激素血症的临床、激素、影像学和免疫组织化学研究的影响。
Eur J Endocrinol. 2011 Nov;165(5):779-88. doi: 10.1530/EJE-11-0542. Epub 2011 Sep 6.
7
A premenopausal woman with virilization secondary to an ovarian Leydig cell tumor.一位绝经前女性，因卵巢睾丸间质细胞瘤导致男性化。
Nat Rev Endocrinol. 2011 Apr;7(4):240-5. doi: 10.1038/nrendo.2011.15. Epub 2011 Feb 15.
8
Clinical syndromes associated with ovarian neoplasms: a comprehensive review.与卵巢肿瘤相关的临床综合征：全面综述。
Radiographics. 2010 Jul-Aug;30(4):903-19. doi: 10.1148/rg.304095745.
9
Leydig-cell-tumor of the ovary that responded to GnRH-analogue administration - case report and review of the literature.卵巢间质细胞瘤对促性腺激素释放激素类似物治疗有反应——病例报告及文献综述
Exp Clin Endocrinol Diabetes. 2010 May;118(5):291-7. doi: 10.1055/s-0029-1225351. Epub 2010 Mar 2.
10
Bilateral Leydig cell tumour of the ovary: a rare cause of virilization in postmenopausal patient.双侧卵巢莱迪希细胞瘤：绝经后患者男性化的罕见原因。
Maturitas. 2007 Jun 20;57(2):214-6. doi: 10.1016/j.maturitas.2006.11.013. Epub 2007 Feb 7.