Cerrahpasa Medical Faculty, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Istanbul, Turkey.
Gynecol Endocrinol. 2011 Apr;27(4):237-40. doi: 10.3109/09513590.2010.490611. Epub 2010 Jun 2.
A 60-year-old woman, presented with hirsutism, male pattern baldness, deepening voice and plethora over the past 5 years. Hormonal evaluation showed markedly elevated serum testosterone level (> 1600 ng/dl) and oestradiol level (220 pg/ml) normal DHEA-SO4 level with suppressed LH and FSH levels. She had markedly erythrocytosis with normal hematological indices. The diagnosis of probable secondary erythrocytosis was made. Trans abdominal ultrasound and CT scan revealed a 14 cm × 11 cm × 9 cm solid pelvic mass. An ovarian androgen secreting tumour was suspected and surgery was performed. Histological examination showed a leydig cell tumour. After the operation testosterone and haematocrit levels returned to normal with regression of clinical symptoms. This is the first case of a leydig cell tumour with an erythropoietic effect of excess testosterone.
一位 60 岁女性，过去 5 年来出现多毛症、男性型脱发、声音变深和面色红润。激素评估显示血清睾丸酮水平（> 1600ng/dl）和雌二醇水平（220pg/ml）显著升高，DHEA-SO4 水平正常，LH 和 FSH 水平受抑制。她有明显的红细胞增多，血液学指标正常。诊断为可能的继发性红细胞增多症。经腹部超声和 CT 扫描显示一个 14cm×11cm×9cm 的实性盆腔肿块。怀疑为卵巢雄激素分泌肿瘤，行手术治疗。组织学检查显示为间质细胞瘤。手术后，睾酮和红细胞压积水平恢复正常，临床症状消退。这是首例具有过多睾酮的促红细胞生成作用的间质细胞瘤。
