局部晚期直肠癌预后不良的独立预测因子：甲酰肽受体 1（FPR1）中的 rs867228。
An independent predictor of poor prognosis in locally advanced rectal cancer: rs867228 in formyl peptide receptor 1 (FPR1).
机构信息
Laboratory of Precision Medicine, Ministry of Health & Welfare Feng Yuan Hospital, Taichung, Taiwan.
Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan.
出版信息
Oncoimmunology. 2021 May 14;10(1):1926074. doi: 10.1080/2162402X.2021.1926074.
Formyl peptide receptor 1 (FPR1) plays a key regulatory role in innate and adaptive immunity. Recently, we reported that the CC genotype of FPR1-E346A (rs867228, c. 1037 A > C) is an independent biomarker for patients with locally advanced rectal cancer (LARC) who received preoperative concurrent chemoradiotherapy (CCRT). Pharmacologic inhibition of FPR1 decreased the migration and infiltration of T lymphocytes into tumor microenvironment after CCRT.
甲酰肽受体 1（FPR1）在先天免疫和适应性免疫中发挥关键的调节作用。最近，我们报道 FPR1-E346A（rs867228，c.1037 A > C）的 CC 基因型是接受术前同期放化疗（CCRT）的局部晚期直肠癌（LARC）患者的独立生物标志物。FPR1 的药理学抑制作用可降低 CCRT 后 T 淋巴细胞向肿瘤微环境的迁移和浸润。
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