CAS Key Laboratory of Magnetic Materials and Devices Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Ningbo 315201 P. R. China.
Zhejiang Province Key Laboratory of Magnetic Materials and Application Technology Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Ningbo 315201 P. R. China.
Adv Sci (Weinh). 2021 Mar 8;8(10):2004208. doi: 10.1002/advs.202004208. eCollection 2021 May.
The multi-mode pain-perceptual system (MMPPS) is essential for the human body to perceive noxious stimuli in all circumstances and make an appropriate reaction. Based on the central sensitization mechanism, the MMPPS can switch between different working modes and thus offers a smarter protection mechanism to human body. Accordingly, before injury MMPPS can offer warning of excessive pressure with normal pressure threshold. After injury, extra care on the periphery of damage will be activated by decreasing the pressure threshold. Furthermore, the MMPPS will gradually recover back to a normal state as damage heals. Although current devices can realize basic functions like damage localization and nociceptor signal imitating, the development of a human-like MMPPS is still a great challenge. Here, a bio-inspired MMPPS is developed for prosthetics protection, in which all working modes is realized and controlled by mimicking the central sensitization mechanism. Accordingly, the system warns one of a potential injury, identifies the damaged area, and subsequently offers extra care. The proposed system can open new avenues for designing next-generation prosthetics, especially make other smart sensing systems operate under complete protection against injuries.
多模式疼痛感知系统 (MMPPS) 对于人体在各种情况下感知有害刺激并做出适当反应至关重要。基于中枢敏化机制，MMPPS 可以在不同的工作模式之间切换，从而为人体提供更智能的保护机制。因此，在受伤前，MMPPS 可以通过正常压力阈值提供过度压力的预警。受伤后，通过降低压力阈值，会在损伤的外围区域激活额外的保护。此外，随着损伤的愈合，MMPPS 将逐渐恢复到正常状态。尽管目前的设备可以实现损伤定位和伤害感受器信号模拟等基本功能，但开发出类似人类的 MMPPS 仍然是一个巨大的挑战。在这里，开发了一种仿生 MMPPS 用于假肢保护，其中通过模拟中枢敏化机制实现和控制所有工作模式。因此，该系统会对潜在的损伤发出警告，识别受损区域，并随后提供额外的保护。所提出的系统可以为设计下一代假肢开辟新途径，特别是使其他智能传感系统在完全免受损伤的情况下运行。
