Dai Tingting, Hu Qinghua, Xie Zhongshang, Li Chunhui
Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.
The Department of Cardiovascular Surgery, Xiangya Hospital, Central South University, Changsha, China.
Front Med (Lausanne). 2021 May 5;8:655640. doi: 10.3389/fmed.2021.655640. eCollection 2021.
Fungal endocarditis (FE) is a rare but fatal disease. The incidence of infective endocarditis (IE) in hemodialysis patients with catheters is thought to be obviously higher than that in the general population. We reported a case of IE caused by () in a 36-year-old woman on hemodialysis. Because the blood cultures were persistently negative, so we used mNGS (Metagenomic next generation sequencing) for early clinical diagnosis. After treatment with voriconazole, the patient's condition improved rapidly. She continued oral voriconazole treatment 1 year after discharge and is in good condition. The diagnosis and treatment strategies of FE in hemodialysis patients were discussed.
真菌性心内膜炎(FE)是一种罕见但致命的疾病。有导管的血液透析患者感染性心内膜炎(IE)的发病率被认为明显高于普通人群。我们报告了一例36岁血液透析女性患者由()引起的IE病例。由于血培养持续阴性,因此我们使用宏基因组下一代测序(mNGS)进行早期临床诊断。伏立康唑治疗后,患者病情迅速改善。出院后她继续口服伏立康唑治疗1年,目前状况良好。文中讨论了血液透析患者FE的诊断和治疗策略。