Shanks D E, Wilson W G
Developmental Pediatrics, Children's Rehabilitation Center, Charlottesville, VA.
Dev Med Child Neurol. 1988 Jun;30(3):383-6. doi: 10.1111/j.1469-8749.1988.tb14565.x.
A child with lobar holoprosencephaly presented with spastic diplegia and mild mental retardation, compounded by attention deficits and hyperactivity. His facial features were normal, and except for borderline microcephaly, there were no other predictors of holoprosencephaly. This patient represents the mild end of the spectrum of the holoprosencephaly malformation complex, which seems to be under-represented in the medical literature. Holoprosencephaly does not appear to have been described previously in association with spastic diplegia. This patient also illustrates the value of CT scans of the head of patients with neurological findings, without specific etiology.
一名患有叶型全前脑畸形的儿童出现痉挛性双瘫和轻度智力发育迟缓，并伴有注意力缺陷和多动症状。他的面部特征正常，除了边缘性小头畸形外，没有其他全前脑畸形的预测指标。该患者代表了全前脑畸形综合征谱系的轻度末端，这在医学文献中似乎报道较少。全前脑畸形此前似乎未被描述与痉挛性双瘫相关。该患者还说明了对有神经学表现但无特定病因的患者进行头部CT扫描的价值。
