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当前肝脂肪变性时代的脱脂策略。

Defatting strategies in the current era of liver steatosis.

作者信息

Mazilescu Laura Ioana, Selzner Markus, Selzner Nazia

机构信息

Ajmera Transplant Program, Toronto General Hospital, Ontario, Canada.

Division of Nephrology, The Hospital for Sick Children, Toronto, Ontario, Canada.

出版信息

JHEP Rep. 2021 Mar 13;3(3):100265. doi: 10.1016/j.jhepr.2021.100265. eCollection 2021 Jun.

DOI:10.1016/j.jhepr.2021.100265
PMID:34027337
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8121960/
Abstract

Liver steatosis is emerging as a major cause of chronic liver disease worldwide, mainly due to the increasing rate of obesity, type 2 diabetes, and metabolic syndrome. Because of the increased incidence of liver steatosis, many organs are currently declined for transplantation despite high demand and waiting list mortality. Defatting strategies have recently emerged as a means of rapidly reducing liver steatosis to expand the pool of available organs. This review summarises advances in defatting strategies in experimental and human models of liver steatosis over the last 20 years.

摘要

肝脂肪变性正成为全球慢性肝病的主要病因，主要归因于肥胖、2型糖尿病和代谢综合征发病率的上升。由于肝脂肪变性发病率增加，尽管需求高且等待名单上有死亡情况，但目前许多器官被拒绝用于移植。脱脂策略最近已成为一种迅速降低肝脂肪变性以扩大可用器官库的方法。本综述总结了过去20年在肝脂肪变性实验模型和人类模型中脱脂策略的进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f312/8121960/e8cd6c624b06/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f312/8121960/d64d87dfe200/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f312/8121960/e8cd6c624b06/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f312/8121960/d64d87dfe200/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f312/8121960/e8cd6c624b06/gr2.jpg

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本文引用的文献

1
Efficacy and Safety of Weight Reduction of the Donor in Hepatic Steatosis for Living Donor Liver Transplantation.供体减重对活体肝移植治疗肝脂肪变性的疗效与安全性
Ann Transplant. 2020 Jul 21;25:e923211. doi: 10.12659/AOT.923211.
2
Improvement of steatotic rat liver function with a defatting cocktail during ex situ normothermic machine perfusion is not directly related to liver fat content.在体外常温机器灌注期间，使用脱脂鸡尾酒改善脂肪肝大鼠的肝功能与肝脂肪含量无直接关系。
PLoS One. 2020 May 12;15(5):e0232886. doi: 10.1371/journal.pone.0232886. eCollection 2020.
3
Novel defatting strategies reduce lipid accumulation in primary human culture models of liver steatosis.
使用基于滤波器的拉曼系统，通过锁相放大在环境光下实时评估肝脏脂肪含量。
Biomed Opt Express. 2022 Sep 9;13(10):5231-5245. doi: 10.1364/BOE.467849. eCollection 2022 Oct 1.
4
A Review of Defatting Strategies for Non-Alcoholic Fatty Liver Disease.非酒精性脂肪肝去脂策略的研究进展。
Int J Mol Sci. 2022 Oct 5;23(19):11805. doi: 10.3390/ijms231911805.
5
Liver transplantation in the era of non-alcoholic fatty liver disease/metabolic (dysfunction) associated fatty liver disease: the dilemma of the steatotic liver graft on transplantation and recipient survival.非酒精性脂肪性肝病/代谢（功能障碍）相关脂肪性肝病时代的肝移植：脂肪变性肝移植对移植及受者生存的困境
Hepatobiliary Surg Nutr. 2022 Jun;11(3):425-429. doi: 10.21037/hbsn-22-9.
6
Genetic and Life Style Risk Factors for Recurrent Non-alcoholic Fatty Liver Disease Following Liver Transplantation.肝移植后复发性非酒精性脂肪性肝病的遗传和生活方式风险因素
Front Nutr. 2022 Jan 14;8:787430. doi: 10.3389/fnut.2021.787430. eCollection 2021.
7
An Update on Usage of High-Risk Donors in Liver Transplantation.肝移植中高风险供体使用情况的最新进展
J Clin Med. 2021 Dec 31;11(1):215. doi: 10.3390/jcm11010215.
新型脱脂策略可减少人原发性肝脂肪变性培养模型中的脂质积累。
Dis Model Mech. 2020 Apr 29;13(4):dmm042663. doi: 10.1242/dmm.042663.
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Ann Transplant. 2020 Jan 10;25:e920677. doi: 10.12659/AOT.920677.
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Liver Transpl. 2019 Jul;25(7):1007-1022. doi: 10.1002/lt.25439.
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An effective protocol for pharmacological defatting of primary human hepatocytes which is non-toxic to cholangiocytes or intrahepatic endothelial cells.一种有效的人原代肝细胞药理学去脂方法，对胆管细胞或肝内内皮细胞无毒。
PLoS One. 2018 Jul 25;13(7):e0201419. doi: 10.1371/journal.pone.0201419. eCollection 2018.
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Cell Biol Int. 2018 Sep;42(10):1282-1291. doi: 10.1002/cbin.11015. Epub 2018 Jul 8.