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Anaphylaxis to the first dose of mRNA SARS-CoV-2 vaccines: Don't give up on the second dose!对第一剂新型冠状病毒mRNA疫苗的过敏反应：不要放弃接种第二剂！
Allergy. 2021 Sep;76(9):2916-2920. doi: 10.1111/all.14958. Epub 2021 Jun 9.
2
Adverse events of special interest and mortality following vaccination with mRNA (BNT162b2) and inactivated (CoronaVac) SARS-CoV-2 vaccines in Hong Kong: A retrospective study.香港接种 mRNA（BNT162b2）和灭活（科兴）SARS-CoV-2 疫苗后特殊关注的不良事件和死亡率：一项回顾性研究。
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IgE-mediated allergy to polyethylene glycol (PEG) as a cause of anaphylaxis to mRNA COVID-19 vaccines.作为对mRNA新冠疫苗过敏反应的一个原因，IgE介导的对聚乙二醇（PEG）过敏
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J Clin Immunol. 2022 Nov;42(8):1593-1599. doi: 10.1007/s10875-022-01350-1. Epub 2022 Aug 17.

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Safety of COVID-19 revaccination in patients with prior hypersensitivity reactions: a retrospective study.既往有过敏反应的患者接种新冠病毒疫苗加强针的安全性：一项回顾性研究
Trop Dis Travel Med Vaccines. 2025 Aug 14;11(1):30. doi: 10.1186/s40794-025-00266-z.
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Adverse reactions to mRNA COVID-19 vaccine in people with allergies in Japan.日本过敏人群对新冠mRNA疫苗的不良反应。
Glob Health Med. 2024 Dec 31;6(6):363-374. doi: 10.35772/ghm.2024.01053.
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Comirnaty-induced cardiopulmonary distress and other symptoms of complement-mediated pseudo-anaphylaxis in a hyperimmune pig model: Causal role of anti-PEG antibodies.在超免疫猪模型中，Comirnaty诱导的心肺窘迫及补体介导的类过敏反应的其他症状：抗聚乙二醇抗体的因果作用
Vaccine X. 2024 May 23;19:100497. doi: 10.1016/j.jvacx.2024.100497. eCollection 2024 Aug.
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J Allergy Clin Immunol Glob. 2023 Oct 5;3(1):100176. doi: 10.1016/j.jacig.2023.100176. eCollection 2024 Feb.
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Allergic reactions to the Ad26.COV2.S vaccine in South Africa.南非对Ad26.COV2.S疫苗的过敏反应。
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Anaphylatoxin Complement 5a in Pfizer BNT162b2-Induced Immediate-Type Vaccine Hypersensitivity Reactions.辉瑞BNT162b2诱导的速发型疫苗超敏反应中的过敏毒素补体5a
Vaccines (Basel). 2023 May 23;11(6):1020. doi: 10.3390/vaccines11061020.
7
Role of anti-polyethylene glycol (PEG) antibodies in the allergic reactions to PEG-containing Covid-19 vaccines: Evidence for immunogenicity of PEG.抗聚乙二醇（PEG）抗体在含 PEG 的 COVID-19 疫苗过敏反应中的作用：PEG 具有免疫原性的证据。
Vaccine. 2023 Jul 12;41(31):4561-4570. doi: 10.1016/j.vaccine.2023.06.009. Epub 2023 Jun 5.
8
Polyethylene Glycol and Polysorbate 80 Skin Tests in the Context of an Allergic Risk Assessment for Hypersensitivity Reactions to Anti-SARS-CoV-2 mRNA Vaccines.在针对抗SARS-CoV-2 mRNA疫苗超敏反应的过敏风险评估背景下进行聚乙二醇和聚山梨酯80皮肤试验
Vaccines (Basel). 2023 Apr 28;11(5):915. doi: 10.3390/vaccines11050915.
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Anaphylaxis induced by mRNA COVID-19 vaccines: follow-up and booster dose after previous desensitization.mRNA新冠疫苗诱导的过敏反应：既往脱敏后的随访及加强剂量
Front Allergy. 2023 May 3;4:1056619. doi: 10.3389/falgy.2023.1056619. eCollection 2023.
10
Skin Testing and Basophil Activation Testing Is Useful for Assessing Immediate Reactions to Polyethylene Glycol-Containing Vaccines.皮肤试验和嗜碱性粒细胞活化试验有助于评估对含聚乙二醇疫苗的速发型反应。
Vaccines (Basel). 2023 Jan 23;11(2):252. doi: 10.3390/vaccines11020252.

本文引用的文献

1
Optimizing investigation of suspected allergy to polyethylene glycols.优化对疑似聚乙二醇过敏的调查。
J Allergy Clin Immunol. 2022 Jan;149(1):168-175.e4. doi: 10.1016/j.jaci.2021.05.020. Epub 2021 May 28.
2
Acute Allergic Reactions to mRNA COVID-19 Vaccines.mRNA COVID-19 疫苗的急性过敏反应。
JAMA. 2021 Apr 20;325(15):1562-1565. doi: 10.1001/jama.2021.3976.
3
Reports of Anaphylaxis After Receipt of mRNA COVID-19 Vaccines in the US-December 14, 2020-January 18, 2021.2020年12月14日至2021年1月18日美国接种mRNA新冠疫苗后发生过敏反应的报告
JAMA. 2021 Mar 16;325(11):1101-1102. doi: 10.1001/jama.2021.1967.
4
Assessing severity of anaphylaxis: a data-driven comparison of 23 instruments.评估过敏反应的严重程度：23种工具的数据驱动比较
Clin Transl Allergy. 2018 Aug 1;8:29. doi: 10.1186/s13601-018-0215-x. eCollection 2018.

Anaphylaxis to the first dose of mRNA SARS-CoV-2 vaccines: Don't give up on the second dose!

作者信息

Krantz Matthew S, Bruusgaard-Mouritsen Maria A, Koo Grace, Phillips Elizabeth J, Stone Cosby A, Garvey Lene H

机构信息

Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.

Department of Dermatology and Allergy, Allergy Clinic, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.

出版信息

Allergy. 2021 Sep;76(9):2916-2920. doi: 10.1111/all.14958. Epub 2021 Jun 9.

DOI:10.1111/all.14958
PMID:34028041
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8222898/
Abstract
摘要