桥本甲状腺炎合并甲状腺乳头状癌：一项 22 年的研究。
Hashimoto's thyroiditis in papillary thyroid carcinoma: a 22-year study.
机构信息
Istanbul Medeniyet University, School of Medicine, Department of Otorhinolaryngology and Head & Neck Surgery, Goztepe Training and Research Hospital, Istanbul, Turkey.
Elazıg Health Practices and Research Center, Department of Otorhinolaryngology and Head & Neck Surgery, Elazıg, Turkey.
出版信息
Acta Otorhinolaryngol Ital. 2021 Apr;41(2):142-145. doi: 10.14639/0392-100X-N1081.
OBJECTIVE
We retrospectively investigated whether there is a relationship between Hashimoto's thyroiditis (HT) and papillary thyroid carcinoma and studied the effect of HT on prognostic factors.
METHODS
1080 patients, who underwent thyroidectomy in our hospital and received a diagnosis of papillary thyroid carcinoma, were included in the study. In histopathological specimens, the diagnosis of papillary thyroid carcinoma was reconfirmed and non-neoplastic areas in the same specimen were evaluated in terms of HT.
RESULTS
HT was detected in non-neoplastic areas of specimens in 36.1% (n = 390) of 1080 patients with a diagnosis of papillary thyroid carcinoma whereas HT was not observed in 63.9% (n = 690). There was a significant positive correlation between presence of HT and multifocal location (p < 0.05, χ2 = 38.5). There was no significant relationship between extrathyroidal tissue invasion and HT (p > 0.05).
CONCLUSION
We assume that patients with HT developing papillary thyroid carcinoma have an increased risk of having multifocal tumour, and thus surgical intervention should be tailored according to this risk.
目的
我们回顾性研究桥本甲状腺炎（HT）与甲状腺乳头状癌之间是否存在关联，并研究 HT 对预后因素的影响。
方法
纳入 1080 例在我院接受甲状腺切除术并诊断为甲状腺乳头状癌的患者进行研究。在组织病理学标本中，重新确认甲状腺乳头状癌的诊断，并评估同一标本中的非肿瘤区域是否存在 HT。
结果
在诊断为甲状腺乳头状癌的 1080 例患者中，有 36.1%（n=390）的标本非肿瘤区域检测到 HT，而 63.9%（n=690）的患者未观察到 HT。HT 的存在与多灶性位置呈显著正相关（p<0.05，χ2=38.5）。HT 与甲状腺外组织侵犯之间无显著关系（p>0.05）。
结论
我们假设患有 HT 的甲状腺乳头状癌患者发生多灶性肿瘤的风险增加，因此应根据这种风险进行手术干预。
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