气相色谱/质谱联用技术对生物材料中硫喷妥钠的毒理学分析。

Toxicological analysis of thiamylal in biological materials by gas chromatography/mass spectrometry.

作者信息

Kudo K, Nagata T, Kimura K, Uehori R, Noda M

机构信息

Department of Legal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

出版信息

Forensic Sci Int. 1988 May;37(3):193-200. doi: 10.1016/0379-0738(88)90184-3.

DOI:10.1016/0379-0738(88)90184-3

PMID:3402859

Abstract

A reliable and sensitive method to analyze thiamylal in biological materials was developed, using gas chromatography/mass spectrometry (GC/MS). A quantitative determination was made by use of mass fragmentography with the lower detection limit of 0.01 microgram/g. Thiopental was used as the internal standard. Distribution of the drug in the blood and body tissues of rats was examined. The method was then used to detect thiamylal in tissues from an autopsied patient and concentration of this drug in the body materials was evaluated, from medico-legal aspects.

摘要

采用气相色谱/质谱联用（GC/MS）技术，开发了一种可靠且灵敏的分析生物材料中硫喷妥钠的方法。通过质量碎片分析法进行定量测定，检测下限为0.01微克/克。以硫喷妥作为内标。研究了该药物在大鼠血液和身体组织中的分布情况。随后，从法医学角度，运用该方法检测了一名尸检患者组织中的硫喷妥钠，并评估了该药物在身体材料中的浓度。