大细胞转化的四期红皮病蕈样肉芽肿经普拉曲沙和罗米地辛联合治疗达到完全缓解，随后行异基因造血干细胞移植。
Complete remission of stage IV erythrodermic mycosis fungoides with large cell transformation through combination of pralatrexate and romidepsin followed by allogeneic hematopoietic stem cell transplantation.
机构信息
School of Medicine, University of Western Australia, Nedlands, Western Australia, Australia.
Department of Haematology, Royal Perth Hospital, Perth, Western Australia, Australia.
出版信息
Australas J Dermatol. 2021 Aug;62(3):e400-e403. doi: 10.1111/ajd.13606. Epub 2021 May 24.
We report the case of a 59-year-old woman with stage IV erythrodermic mycosis fungoides (MF) and large cell transformation who, despite failing multiple previous treatments, achieved complete remission through a combination of pralatrexate and romidepsin followed by allogeneic hematopoietic stem cell transplantation (alloSCT). Further studies are needed in focussing on this combined regimen in treating cutaneous T-cell lymphoma (CTCL) and its efficacy as a bridging regimen in facilitating successful alloSCT.
我们报告了一例 59 岁女性患者，患有 IV 期红皮病蕈样真菌病（MF）和大细胞转化，尽管之前的多种治疗均失败，但通过联合普拉曲沙和罗米地辛治疗后，再进行异基因造血干细胞移植（alloSCT），达到完全缓解。需要进一步研究这种联合方案治疗皮肤 T 细胞淋巴瘤（CTCL）及其作为桥接方案促进成功 alloSCT 的疗效。
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