经皮乙醇注射（PEI）治疗甲状腺囊实性结节的长期疗效和安全性：系统评价和荟萃分析。
Long-term efficacy and safety of percutaneous ethanol injection (PEI) in cystic thyroid nodules: A systematic review and meta-analysis.
机构信息
Ospedale Santa Maria Goretti, Latina, Italy.
Unit of Endocrinology and Diabetes, Campus Bio-Medico University, Rome, Italy.
出版信息
Clin Endocrinol (Oxf). 2022 Feb;96(2):97-106. doi: 10.1111/cen.14530. Epub 2021 Jun 16.
BACKGROUND
Percutaneous ethanol injection (PEI) is used for the treatment of benign cystic thyroid nodules. This systematic review and meta-analysis aimed to obtain strong evidence of its long-term efficacy and safety.
METHODS
PubMed, CENTRAL, Scopus and Web of Science databases were searched until November 2020 for studies reporting data on volume reduction rate (VRR), compressive symptoms and cosmetic concerns. Associated complications were assessed. A random-effects model was designed to pool the data.
RESULTS
Out of 385 papers, nine studies evaluating 1667 nodules were finally included. Overall, VRR at 6, 12, 24, 36, 60 and 120 months was 77%, 81%, 72%, 68%, 74% and 69%, respectively. Significant reductions in the compressive symptoms and cosmetic concerns were observed. No permanent complications were observed.
CONCLUSIONS
The present meta-analysis showed that PEI could significantly reduce the volume of benign cystic thyroid nodules. This reduction was already effective at 6 months post-treatment, and the effect was stable over time.
背景
经皮乙醇注射（PEI）用于治疗良性囊性甲状腺结节。本系统评价和荟萃分析旨在获得其长期疗效和安全性的有力证据。
方法
检索 PubMed、CENTRAL、Scopus 和 Web of Science 数据库，截至 2020 年 11 月，检索报告体积缩小率（VRR）、压迫症状和美容问题数据的研究。评估相关并发症。采用随机效应模型对数据进行合并。
结果
在 385 篇论文中，最终纳入了 9 项研究共 1667 个结节。总体而言，6、12、24、36、60 和 120 个月时的 VRR 分别为 77%、81%、72%、68%、74%和 69%。观察到压迫症状和美容问题显著减轻。未观察到永久性并发症。
结论
本荟萃分析表明，PEI 可显著缩小良性囊性甲状腺结节的体积。这种减少在治疗后 6 个月时已经有效，并且效果随时间稳定。
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