Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Biotechnol Appl Biochem. 2022 Jun;69(3):1300-1310. doi: 10.1002/bab.2203. Epub 2021 Aug 7.
We aimed to define specific reference intervals (RIs) for 11 biomarkers including inflammatory and oxidative stress biomarkers, liver, and renal function tests in a healthy Iranian adult population for the first time.
CLSI Ep28-A3 guidelines were then used to calculate accurate age- and sex- as well as body mass index (BMI)-specific RIs.
RIs for studied biomarkers showed no significant age and sex-specific differences, except for uric acid, which had higher concentrations in men when compared to women. Additionally, after partitioning the participants based on the BMI with a cutoff point of 25 kg/m , only the levels of hs-CRP were positively associated with higher BMI (RI for BMI>25: 0.51-7.85 mg/L and for BMI<25: 0.40-4.46 mg/L). RI for PAB and anti-hsp-27 were reported 4.69-155.36 HK and 0.01-0.70 OD in men and women aged 35-65 years old.
Partitioning by sex and BMI was only required for uric acid and hs-CRP, respectively, while other biomarkers required no partitioning. These results can be expected to valuably contribute to improve laboratory test result interpretation in adults for improved monitoring of various diseases in the Iranian population.
我们旨在首次为伊朗健康成年人定义 11 种生物标志物（包括炎症和氧化应激生物标志物、肝功能和肾功能试验）的特定参考区间（RI）。
然后使用 CLSI Ep28-A3 指南计算准确的年龄、性别和体重指数（BMI）特异性 RI。
除尿酸外，研究生物标志物的 RI 无明显的年龄和性别特异性差异，与女性相比，男性尿酸浓度更高。此外，根据 BMI 进行分组（截断点为 25 kg/m ）后，仅 hs-CRP 水平与较高的 BMI 呈正相关（RI 对于 BMI>25：0.51-7.85 mg/L，对于 BMI<25：0.40-4.46 mg/L）。RI 对于 PAB 和抗 hsp-27 的报告值为男性和女性 35-65 岁时的 4.69-155.36 HK 和 0.01-0.70 OD。
尿酸和 hs-CRP 分别需要按性别和 BMI 进行分组，而其他生物标志物则不需要分组。这些结果有望为改善伊朗人群各种疾病的监测提供有价值的实验室检测结果解释。
