Oluwasanmi Adeolu, Hoskins Clare
Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1 1RD, UK.
Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1 1RD, UK.
Int J Pharm. 2021 Jul 15;604:120727. doi: 10.1016/j.ijpharm.2021.120727. Epub 2021 May 23.
The Diels-Alder reaction and its retro breakdown has garnered increasing research focus due to several of its advantageous properties including, atomic conservation, reversibility, and substituent retention. This is especially true in biomedical application and nanomedicine development which display a preference for rapid, efficient, and clean "click" chemistry reactions allowing for delivery of active ingredients and subsequent release upon temperature elevation. There are multiple variations on the Diels-Alder reaction based around substitution position and materials being coupled which can affect the temperature threshold for and rate of the retro reaction reversal. Hence, the Diels-Alder reaction offers a simple coupling reaction for active ingredients with tailorable release. In this review the incorporation of the Diels-Alder chemistries and linkers within the biomedical and nanomedicine field will be discussed, as well as its use in future potential technologies.
狄尔斯-阿尔德反应及其逆向分解反应因其诸多优势特性，包括原子守恒、可逆性和取代基保留等，而受到越来越多的研究关注。在生物医学应用和纳米医学发展领域尤其如此，这些领域倾向于快速、高效且清洁的“点击”化学反应，以便实现活性成分的递送以及随后在温度升高时释放。基于取代位置和所连接的材料，狄尔斯-阿尔德反应有多种变体，这可能会影响逆向反应逆转的温度阈值和速率。因此，狄尔斯-阿尔德反应为活性成分提供了一种可定制释放的简单偶联反应。在本综述中，将讨论狄尔斯-阿尔德化学及其连接体在生物医学和纳米医学领域的应用，以及其在未来潜在技术中的用途。
