大鼠单侧肾切除术后的糖尿病性肾小球病变
Diabetic glomerulopathy following unilateral nephrectomy in the rat.
作者信息
Steffes M W, Brown D M, Mauer S M
出版信息
Diabetes. 1978 Jan;27(1):35-41. doi: 10.2337/diab.27.1.35.
One month following induction of diabetes with streptozotocin, one half of diabetic and control rats underwent unilateral nephrectomy. Subsequently, all animals were studied with respect to renal function and glomerular alterations of diabetes. Blood pressure levels were similar in all animals. Diabetic and control animals with unilateral nephrectomy had similar but elevated serum creatinine levels and lower creatinine clearance values as compared with the intact rats. However, on a per kidney basis the creatinine clearance levels were higher in the animals with unilateral nephrectomy. At both three and six months following nephrectomy, markedly increased mesangial matrix thickening and mesangial deposition of IgG and C3 were observed in diabetic rats with unilateral nephrectomy as compared with intact diabetic animals. Nephrectomy had no detectable effects on glomerular morphology or immunohistochemistry of nondiabetic rats. Thus, unilateral nephrectomy in the rat increases, at as early as three months, the severity of diabetic glomerular lesions.
用链脲佐菌素诱导糖尿病一个月后，一半的糖尿病大鼠和对照大鼠接受了单侧肾切除术。随后，对所有动物的肾功能和糖尿病的肾小球改变进行了研究。所有动物的血压水平相似。与完整大鼠相比，接受单侧肾切除术的糖尿病和对照动物的血清肌酐水平相似但升高，肌酐清除率值较低。然而，以每只肾脏计算，单侧肾切除动物的肌酐清除率水平较高。在肾切除术后三个月和六个月时，与完整的糖尿病动物相比，接受单侧肾切除术的糖尿病大鼠系膜基质明显增厚，IgG和C3的系膜沉积增加。肾切除术对非糖尿病大鼠的肾小球形态或免疫组化没有可检测到的影响。因此，大鼠单侧肾切除术早在三个月时就会增加糖尿病肾小球病变的严重程度。
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