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SARS-CoV-2 与 HIV 合并感染且 CD4+T 细胞计数低。

Coinfection between SARS-CoV-2 and HIV with a low CD4+ T-cells count.

机构信息

Udayana University, Medical Faculty, Denpasar, Bali, Indonesia.

出版信息

Med J Malaysia. 2021 May;76(3):446-448.

PMID:34031352
Abstract

Coronavirus Disease 2019 (COVID-19) is an acute respiratory infectious disease caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection that started in Wuhan, China in December 2019 and has spread rapidly worldwide. It's critical to take extra precautions if a person has chronic illnesses (comorbidities), such as human immunodeficiency (HIV) infection. Concerns about people living with HIV (PLHIV) having a higher risk of serious COVID-19 disease may be based on the assumption that PLHIV are more likely to be immunocompromised. On the other hand, limited information is available in such people about the characteristics of co-infection between SARS-CoV-2 and Human Immunodeficiency Virus (HIV) who are at greater risk than the general population. Our findings, is of a 32 year old patient who came to Emergency Unit of Wangaya Hospital, Medical Faculty, Udayana University in Denpasar, Bali with complaint of fever, dry cough, and shortness of breath since prior 3 days and had also the past history prolonged fever, weight loss more than 10% 4 weeks. Diagnosis of COVID-19 was confirmed by nasopharyngeal swab sample was used for RT-PCR assay and PITC to confirm HIV infection. He had prolonged hospitalized and discharge after 18 days.

摘要

2019 年冠状病毒病(COVID-19)是一种由严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)感染引起的急性呼吸道传染病,于 2019 年 12 月在中国武汉开始,并迅速在全球范围内传播。如果一个人患有慢性疾病(合并症),如人类免疫缺陷(HIV)感染,就必须采取额外的预防措施。人们担心感染艾滋病毒的人(PLHIV)患严重 COVID-19 疾病的风险更高,可能是基于这样的假设,即 PLHIV 更有可能免疫功能低下。另一方面,在感染 SARS-CoV-2 和人类免疫缺陷病毒(HIV)的风险较高的人群中,关于此类人群中 SARS-CoV-2 和 HIV 合并感染特征的信息有限。我们的研究结果来自一名 32 岁的患者,他因发热、干咳和呼吸急促前 3 天到巴厘岛登巴萨的望加锡医院、乌达亚纳大学医学院急诊部就诊,并有长期发热、体重减轻超过 10%4 周的病史。COVID-19 的诊断通过鼻咽拭子样本进行 RT-PCR 检测和 PITC 检测来确认 HIV 感染。他在住院 18 天后出院。

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