School of Medicine, Monash University, Melbourne, VIC, Australia.
Sports Cardiology, Baker Heart and Diabetes Institute, 75 Commercial Rd, Melbourne, VIC, 3004, Australia.
Eur J Appl Physiol. 2021 Sep;121(9):2499-2507. doi: 10.1007/s00421-021-04720-6. Epub 2021 May 25.
Exercise oscillatory ventilation (EOV) is a form of periodic breathing that is associated with a poor prognosis in heart failure patients, but little is known about EOV in other populations. We sought to provide insights into the phenomenon of EOV after it was observed in young healthy subjects, including athletes, after the administration of dual autonomic blockade (DAB).
From 29 participants who completed cardiopulmonary exercise testing (CPET) with and without DAB (0.04 mg/kg atropine and 0.2 mg/kg metoprolol), 5 subjects developed EOV (age = 29 ± 5 years; 3/5 were athletes) according to American Heart Association criteria. For each case, we identified 2 non-EOV healthy controls (age = 34.2 ± 8.3; 7/10 were athletes) that were subsequently age- and sex-matched.
No participants had EOV during exercise without DAB. The 5 participants (4 male, 1 female) who demonstrated EOV with DAB had lower mean tidal volume (1.7 ± 0.5 L/min vs. 1.8 ± 0.5 L/min; p = 0.04) compared to participants in the non-EOV group and a decrease in peak tidal volume (2.9 ± 0.6 L/min to 2.2 ± 0.7 L/min; p = 0.004) with DAB. There were few other differences in CPET measures between EOV and non-EOV participants, although the PETCO2 tended to be higher in the EOV group (p = 0.07).
EOV can be elucidated in young healthy subjects, including athletes, during cardiopulmonary exercise testing, suggesting that it may not be an ominous sign in all populations.
运动性振荡通气（EOV）是一种周期性呼吸形式，与心力衰竭患者的预后不良相关，但对于其他人群中的 EOV 知之甚少。我们试图在年轻健康受试者（包括运动员）中观察到 EOV 后，提供有关其现象的深入了解，这些受试者在接受双重自主神经阻断（DAB）后出现了 EOV。
从 29 名完成心肺运动测试（CPET）并接受和不接受 DAB（0.04mg/kg 阿托品和 0.2mg/kg 美托洛尔）的参与者中，有 5 名根据美国心脏协会标准出现 EOV（年龄=29±5 岁；3/5 为运动员）。对于每个病例，我们确定了 2 名无 EOV 的健康对照者（年龄=34.2±8.3 岁；7/10 为运动员），然后按年龄和性别匹配。
在没有 DAB 的运动中，没有参与者出现 EOV。在接受 DAB 后出现 EOV 的 5 名参与者（4 名男性，1 名女性）的平均潮气量较低（1.7±0.5 L/min 比 1.8±0.5 L/min；p=0.04），与非 EOV 组相比，峰值潮气量下降（2.9±0.6 L/min 至 2.2±0.7 L/min；p=0.004）。在 EOV 和非 EOV 参与者之间，CPET 测量值之间几乎没有其他差异，尽管 EOV 组的 PETCO2 趋势较高（p=0.07）。
在心肺运动测试期间，包括运动员在内的年轻健康受试者中可以阐明 EOV，这表明它在所有人群中可能不是一个不祥的迹象。
